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时辰化疗作用机制的生物学研究进展 被引量：22

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摘要 “时间生物学”是近年来生命科学研究的热点。已知所有生命活动均遵循一定的生物节奏周而复始地进行，如：正常组织及靶组织细胞DNA合成、药物代谢限速酶的活性、药物敏感性相关基因的表达及药物代谢活动等节律。随着生物节律调节基因在哺乳类乃至人类中的定位和克隆，生命科学对“生物钟”的研究连续两年被国际权威杂志（科学Science）评为“可能改变人类对自然的认识，从而产生重大社会和经济效益的、有重大突破的研究领域”，成为近年生命科学领域的研究热点。
作者 陈昕 梁超 雷开键 贾钰铭 杜一平
机构地区 四川省宜宾市第二人民医院肿瘤科 宜宾市第二人民医院心内科
出处 《现代预防医学》 CAS 北大核心 2008年第2期201-202,207,共3页 Modern Preventive Medicine
基金 吴阶平医学基金会立项资助课题(87-A)
关键词 肿瘤 昼夜节律 时辰治疗 化疗 时间生物学 作用机制
分类号 R453 [医药卫生—治疗学]
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参考文献18

  • 1郭灵,林焕新,冼励坚.恶性肿瘤时辰化疗的基础理论及实践[J].中国肿瘤临床,2004,31(1):56-59. 被引量：33
  • 2Teresa G. G, Elisabeth F, P. Vrignaud, et al. Rhythm of expression of BCL-2 protein of MA13/C mammaryadenocarcinoma bearing-mice [J]. Pathologie Biologie, 2003, 51 (4): 220-221
  • 3Xian L.J, Sun J, Cao Q.Y, et al. Circadian Rhythms of DNA Synthesis in Nasopharyngeal Carcinoma Cells [J]. Chronobiol. Int, 2002, 19 (1), 69-76.
  • 4Hori K, Zhang QH, Li HC, Timing of cancer chemotherapy based on circadian variations in tumor tissue blood flow [J]. Int J Cancer, 1996, 65 (3): 360-3641.
  • 5Reppert, S. M, Weaver, D. R. Coordination of circadian timing in mammals [J]. Nature (Lond.), 2002, 418: 935-941.
  • 6Terzoli E, Garufi C, Zappala AR, et al. High-dose chronomodulated infusion of 5-fluorouracil (5-FU) and folinic acid (FA) (FF5-16) in advanced colorectal cancer patients [J]. J Cancer Res Clin Oncol, 2004, 130 (8): 445--4522.
  • 7Bjarnason, G.A, Jordan, R.C, Wood, P.A, et al. Circadian Expression of clock Genes in Human Oral Mucosa and Skin : Association with Specific Cell-Cycle Phases [J]. Am. J. Pathol, 2001, 158 (5): 1793-1801.3.
  • 8Petit E, Milano G, Levi F, et al. Circadian Varying Plasma Concentration of 5- fluorouracil During 5-Day Continuous Venous Infusion at Constant Rate in Cancer Patients [J]. Cancer Res, 1988, 48 (6): 1676-1679.
  • 9Harris BE, Song R, Soong sj, et al. Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil level: evidence for circadian variation of plasma drug level in cancer patients receiving 5-fluorouracfil by protracted continuous infusion [J]. Cancer Res, 1990, 50 (1): 197-201.
  • 10Hrushesky WJM, Bjarnason, GA.Circadian Cancer Therapy [J]. J Clin Oncol, 1993, 11 (7): 1403-1417.

二级参考文献31

  • 1[1]Dunlap J C. Molecular Base for Circadian Clock[J]. Cell,1999,96(2): 271～290
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  • 6[6]Granda TG, Filipski E, D'Attino RM, et al. Experimental Chronotherapy of Mouse Mammary Adenocarcinoma MA13/C with docetaxel and Doxorubicine as Single Agent and in Combination[J]. Cancer Res, 2001, 61(5): 1996～2001
  • 7[7]Smaaland R, Sothern R B, Laerum O D, et al. Rhythm in Human Bone Marrow and Blood Cells [J]. Chronobiol Int,2002, 19(1): 101～127
  • 8[8]Bjarnason GA, Jodan R. Rhythm in Human gastrointestinal Mucosa and Skin[J]. Chronobiol Int, 2002, 19(1): 129～140
  • 9[9]Harris BE, Song R, Soong SJ, et al. Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil level: evidence for circadian variation of plasma drug level in cancer patients receiving 5-fluorouracil by protracted continuous infusion[J]. Cancer Res, 1990, 50(1): 197～201
  • 10[10]Petit E, Milano G, Lévi F, et al. Circadian Varying Plasma Concentration of 5-Fluorouracil During 5-Day Continuous Venous Infusion at Constant Rate in Cancer Patients[J]. Cancer Res, 1988, 48(6): 1676～1679

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现代预防医学
2008年 第2期

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