摘要
比较研究健康鸡和多型艾美尔球虫混合感染鸡饮水(3 mg/L,连续自由饮水9 d)地克珠利后在血浆、皮肤+脂肪、肝脏、肾脏、肌肉组织中的残留量,用甲醇提取血浆中的药物,用乙腈提取组织中的药物,用高效液相色谱法测定。结果表明,感染鸡组织中的残留量比健康鸡组织中的残留量要低,消除更快,说明肉鸡的多型艾美尔球虫混合感染对地克珠利在其体内的残留和消除规律有一定的影响。
In this study residues of diclazuril were compared in the plasma, skin -fat, liver, kidney and muscle of health chicken and the chicken infected with Eimeria （3 mg/L, freely drinking for 9 days successively）. Methanol and acetonitrile were used to extract drug from plasma and tissues respectively, then diclazuril concentration was determined by high performance liquid chromatography. The results showed that the residues of diclazuril in tissues of chickens infected with Eimeria was lower than the healthy group and its elimination is faster, this showed that mixed infection with Eimeria has a certain influence on residues and elimination of diclazuril.
出处
《中国兽药杂志》
2008年第1期15-17,共3页
Chinese Journal of Veterinary Drug
