摘要
目的使用受试者工作特征曲线(ROC曲线),评价化学发光分析法(CLIA)检测前列腺特异性抗原(prostatespecific antigen,PSA)对前列腺癌的诊断价值,确定临床判断前列腺癌的最佳临床阈值。方法CLIA法检测前列腺癌患者血清PSA,并用ROC曲线进行分析。结果该试验经ROC曲线分析,确定最佳阈值为5.35ug/L,此点灵敏度为70.6%、特异度为81.8%,ROC曲线下面积(ACUROC)0.72,说明CLIA法检测血清PSA在临床上对前列腺癌的诊断有一定准确性。结论使用ROC曲线可确定CLIA法检测血清PSA在前列腺癌诊断时的最佳临界阈值,并判断其临床诊断价值。
Objective To use receiver operating characteristic （ROC） curves for evaluating diagnostic value of chemiluminescence analysis （CLIA） method in detecting prostatespecific antigen （PSA） and determining optimal threshold value in patients with prostate cancer. Methods CLIA method was used to assess PSA for patient suspected prostate cancer, and the test results were analyzed by ROC curves. Results The optimal threshold value was 5.35 ug/L, which had a sensitivity of 70.6 % and a specificity of 81.8 %. The area under the ROC curve （ACU^ROC ） was 0.72. The results demonstrated reliability and validity in clinical diagnostic work - up. Conclusions ROC curves are valid in detection of PSA and determination of optimal threshold value for diagnosis of prostate cancer by CLIA method.
出处
《实用预防医学》
CAS
2007年第6期1892-1893,共2页
Practical Preventive Medicine
关键词
前列腺特异性抗原
前列腺癌
化学发光分析法
受试者工作特征曲线
Prostate- specific antigen （PSA）
Prostate cancer
Chemiluminescence analysis （CLIA） method
Receiver operating characteristic （ROC） curves
