摘要
对23例原发性高血压（EH）、36例冠心病（CHD）和30例健康人血清NO、SOD和LPO其中CHD组包括15例急性心肌梗塞（AMI）和21例非梗塞性CHD水平的测定．结果表明，EH组血清NO水平较健康对照组显著降低（P＜0.01），而SOD活性无显著性差异；在CHD组中，与健康对照组比较，NO和SOD水平均显著降低（P＜0．01），其中，非梗塞性CHD组的NO和SOD水平也均显著降低（P＜0.01），AMI组与对照组间均无显著性差异（P＜0．01）；另外，AMI组较非梗塞组SOD活住显著位增高（P＜0.01），NO水平虽有增高但无显著性意义；所有各患者组血清LPO均显著高于健康对照组（P＜0．01）．结果提示，在心血管疾病发生发展过程中，NO与氧自由基之间存在着相互关系。
The relationship between serum No and SOD, LPO levels of cardiovascu1ar diseases were studied in 23patients with essential Hypertension (EH), 36 patients with CHD (15 AMI and 21 non-AMI) and 30 controls. Much lower NO levels were observed in patients with EH (P < 0. 01 ), the changes of SOD were not sigfnificant. in CHD group, patients demonstrated lower NO and SOD levels than controls (P < 0. 01 ), and so were patients with non-AMI but no significant change between patient with AMI and controls. Moreover, SOD level in patient with AMI was higher than that in patients with non-AMI (P < 0. 01 ), but the NO Levels were increased also although not significant. The serum LPO of all groups had higher levels than the controls (P < 0. 01 ).These results suggest that there is relationship between NO and oxide radical in the formation and development of myocardiol-vascular diseases.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
1997年第4期209-210,共2页
Chinese Journal of Gerontology
关键词
高血压
冠心病
超氧化物歧化酶
过氧化脂质
NO
Cardiovscular Diseases Nitric Oxide Superoxide Dismutase Lipid Peroxide
