子痫前期患者胎盘组织中细胞间黏附分子1的表达被引量：2

Expression of intercellular adhesion molecule-1 in placenta tissue of pre-eclampsia patients

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摘要目的:检测子痫前期患者和正常孕妇胎盘组织中细胞间黏附分子-1(ICAM-1)的表达水平,探讨其在子痫前期发病机制中的作用。方法:采用免疫组化PV-9000法检测50例子痫前期患者(其中轻度子痫前期20例,重度子痫前期30例)和30例正常孕妇子宫胎盘绒毛合体滋养细胞ICAM-1的表达情况。结果:重度子痫前期患者胎盘绒毛合体滋养细胞ICAM-1的表达明显高于正常孕妇组和轻度子痫前期组(P<0.05),轻度子痫前期组与正常孕妇组ICAM-1的表达差异无统计学意义(P>0.05)。结论:重度子痫前期患者胎盘绒毛合体滋养细胞ICAM-1的表达增强,可能通过引起母胎界面炎症反应而参与子痫前期的发病。 Aim： To detect the expressions of intercellular adhesion molecule-1 （ ICAM-1 ） in the placenta tissue of pre-eclampsia and normal pregnant women, and to explore the role of ICAM-1 in the etiology of pre-eclampsia. Methods： The expression of ICAM-1 in placenta tissue of 50 women with pre-eclampsia including 30 women with severe preeclampsia and 20 women with mild pre-eclampsia and 30 normal pregnant women were evaluated by PV-9000 Polymer Detection System（immunohistochemistry）. Results：The expression of ICAM-1 in placenta tissue of severe pre-eclampsia patients was significantly higher than that of mild pre-eclampsia patients and normal pregnant women （ P 〈 0. 05 ） , while there was no difference in the expression of ICAM-1 between the mild pre-eclampsia patients and normal pregnant women （P 〉 0. 05 ）. Conclusion ： The expression of ICAM-1 in the placenta tissue in severe pre-eclampsia patients increased, which may relate to the inflammatory reaction in maternal/fetal interface and leads to pre-eclampsia.

作者袁恩武赵明耀张曦贾莉婷张展

机构地区郑州大学第三附属医院检验科郑州大学基础医学院病理生理学教研室郑州大学第三附属医院妇产科

出处《郑州大学学报（医学版）》 CAS 北大核心 2008年第1期71-73,共3页 Journal of Zhengzhou University(Medical Sciences)

基金河南省科技攻关基金资助项目0624410050

关键词子痫前期细胞间黏附分子-1 胎盘组织 pre-eclampsia intercellular adhesion molecule-1 placenta tissue

分类号 R714.24 [医药卫生—妇产科学]

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参考文献7

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