摘要
在自身免疫性甲状腺疾病（AITD）中，甲状腺过氧化物酶抗体（TPOAb）滴度有不同程度的升高，这对AITD的分类及预后有指导意义。最近研究表明，甲状腺组织甲状腺过氧化物酶（TPO）的异常表达或者血清中TPO含量的变化为甲状腺肿瘤的诊断提供了一种新的途径。另外，部分先天性甲状腺疾病的发生也与TPO基因突变相关。进一步研究TPO及TPOAb，有助于对甲状腺疾病病因的探讨并加深对甲状腺疾病诊断及治疗的认识。
Thyroid peroxidase antibody（TPOAb） titer increases differently in autoimmune thyroid disease（AITD）. This will be helpful to identify the type of AITD and determine the prognosis. Abnormal expression of thyroid peroxidase（TPO） in thyroid or the change of TPO in serum can be used to distinguish the character of thyroid nodule. Besides ,TPO gene mutation leads to congenital thyroid diseases. Further research of TPO and TPOAb will deepen the cognition of the pathogenesis of thyroid diseases and will be helpful to the diagnosis and therapy of thyroid diseases.
出处
《国际内分泌代谢杂志》
2008年第1期62-65,共4页
International Journal of Endocrinology and Metabolism
