摘要
目的建立毛细管气相色谱法测定唑尼沙胺中的有机溶剂残留量。方法用DB-624毛细管气相色谱柱，FID检测器，以正丙醇为内标进行测定。结果甲醇、乙醇、乙酸乙酯、乙酸的线性范围分别为15．029～240．464mg·L^-1（r=0.9999）、24．964～399．424mg·L^-1（r=1）、25．02～400，32mg·L^-1（r=0.9999）、24.99～399.84mg·L^-1（r=0．9999）；甲醇、乙醇、乙酸乙酯、乙酸的平均回收率分别为99．5％、99．0％、98.9％、99.2％；RSD分别为1.2％、1．4％、1．2％、1．5％1（n=9）。结论方法简单、灵敏、准确、重现性好，适用于唑尼沙胺中的有机溶剂残留量的测定。
Objective To develop a gas chromatography method for the determination of residual organic solvents in zonisamid. Methods The samples were injected into DB-624 capillary column and analyzed with FID detector using n-propyl alcohol as the internal standard. Results The linear ranges of methanol, ethanol, ethyl acetate, acetic acid were 15. 029 - 240. 464 mg·L^-1 （ r = 0. 999 9）, 24. 964 - 399. 424 mg·L^-1（ r = 1 ）, 25.02 - 400.32 mg·L^-1（ r = 0. 999 9）, 24.99 - 399.84 mg·L^-1（ r = 0. 999 9）, respectively. The recoveries were 99.5%,99.0%,98.9%,99.2% ;RSD were 1.2%, 1.4%, 1.2%, 1.5% （n =9）, respectively. Conclusions The method is simple, accurate and sensitive with good reproducibility. It can be used for the determination of the residual organic solvents in zonisamide.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2008年第1期56-59,共4页
Journal of Shenyang Pharmaceutical University
