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潍坊地区汉族献血者血小板特异性抗原HPA-1-16系统基因多态性研究 被引量:13

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摘要 目的研究汉族人群血小板特异性抗原HPA-1-16系统基因多态性区域分布特点,建立HPA基因型资料库。方法采用PCR-SSP技术对102名潍坊地区汉族无血缘关系的志愿捐献血小板者作HPA-1-16系统基因分型,计算基因型频率、基因频率。结果从HPA-1、5、6系统分别检出1例a/b基因型,HPA-4系统检出2例a/b基因型,检出HPA-2a/2b 11例(基因频率占0.1078);HPA-3、15系统表现出较高的杂合度,其中3a/3a、3a/3b、3b/3b基因型频率分别为0.3039、0.5392、0.1569,15a/15a、15a/15b、15b/15b基因型频率分别为0.3529、0.4608、0.1863;HPA- 7-14、16系统只检出a基因,呈单特异性。结论潍坊地区汉族人HPA-2、3、15系统具有多态性,是HPA配合性输注关注重点。在随机输血中供受者HPA-2系统不配合的机会为9.68%、HPA-3系统不配合的机会为36.95%、HPA-15系统不配合的机会为36.8%。
出处 《中国输血杂志》 CAS CSCD 2008年第1期31-33,共3页 Chinese Journal of Blood Transfusion
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参考文献12

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二级参考文献39

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