摘要
核因子-κB(nuclearfactor-kappaB,NF-κB)是一个广泛存在于细胞中具有多向调节作用的核转录因子,在细胞生长分化、增殖、凋亡、免疫应答、炎症反应等生理及病理过程中发挥重要的调节作用。NF-κB的活化是炎症反应的中心环节,NF-κB的过度活化与许多急慢性炎性相关疾病的发生发展密切相关。近年的研究显示NF-κB在眼科多种疾病的发病机制中占有重要的地位,尤其是眼表疾病、青光眼、葡萄膜病、白内障、眼底病等,针对NF-κB活性的抑制可能成为眼科新型药物的治疗靶点。本文将对NF-κB与眼科相关疾病的研究报道进行综述。
Nuclear factor-kB（NF-kB） regulates the transcription of a wide array of gene products, which is involved in many pathological and physiological processes, such as cell differentiation, proliferation, apoptosis, and immune/inflammatory reactions. Activation of NF-kB may be a pivotal event in proinflammatory signal transduction. But, its excessive activation would lead to many diseases with severe chronic/acute inflammatory responses. Recently studies showed that NF-KB plays an important role in many eye diseases, such as ocular surface disease, glaucoma, uveitis, cataract, ocular fundus disease and so on. The inhibition of NF-KB activity may be a new therapeutic target in ophthalmology. The present article reviewed the research advances of NF-KB and relevant oc-ulopathy.
出处
《国际眼科杂志》
CAS
2008年第1期132-136,共5页
International Eye Science
关键词
NF-KB
眼病
炎症
nuclear factor KB
oculopathy
inflammation
