摘要
目的探讨丙戊酸钠(VPA)对癫患儿体质量、体质量指数(BMI)、血糖、血清胰岛素水平的影响。方法以VPA治疗3个月的30例癫患者作为研究对象,进行治疗前后自身对比研究,检测患者治疗前及治疗后3个月时体质量、BMI、身高、血糖、血清胰岛素水平,比较治疗前后体质量、BMI、血糖、血清胰岛素、胰岛素抵抗指数变化。利用放射免疫分析法检测其血胰岛素水平。采用SPSS10.0软件进行统计学分析。结果癫患儿治疗后体质量[(15.68±3.82)kgvs(19.64±4.75)kg,t=3.56P<0.01]、BMI[(18.29±2.91)kg/m2vs(20.16±2.71)kg/m2,t=2.13P<0.05]、胰岛素(4.42±0.39)mU/Lvs(6.89±0.41)mU/L,t=24.7P<0.01)、胰岛素抵抗指数(0.96±0.19vs1.45±0.21,t=9.4P<0.01)均较VPA治疗前明显增高。而血糖水平较治疗前无明显增高[(4.42±0.23)mmol/Lvs(4.39±0.35)mmol/L,t=0.39P<0.05]。结论VPA治疗可引起癫患儿体质量、BMI、血清胰岛素水平增高,并导致胰岛素抵抗;诱导胰岛素抵抗可能是VPA患儿体质量增加的原因之一。但对其血糖无直接影响。
Objective To explm＇e the changes of weight, body mass index （ MBI ）, serum glucose, serum insulin in sodium valproate （VPA） - treated children with epilepsy. Methods The study was carried out in 30 epileptic children treated with VPA for 3 months. Weight, height, serum glucose and insulin levels were conducted before and after VPA treatment. Serum insulin levels were detected by radioimmunoassay. Results Mter3 months＇ treatment,body weight [（15.68±3.82） kgvs （19.64±4.75） kg,t=3.56 P〈0.01],BMI[（18.29± 2.91） kg/m^2vs （20.16±2.71） kg/m^2,t =2.13 P〈0.05],serum insulin levels[（4.42±0.39） mU/Lvs （6.89 ± 0.41） mU/L,t= 24.7 P〈0. 011 ,insulin resistance index （0.96 ±0. 19 vs 1.45 ±0.21 ,t =9.4 P〈0.01） were significantly increased eampared with before treatment. But serum insulin level had no significantly increase [ （4.42 ± 0. 23 ） mmol/L vs （4.39 ± 0. 35 ） retool/L, t = 0.39 P 〉 0. 05 ]. Conclusions VPA therapy can make insuline weight, BMI, serum insulin increased and may lead to insulin resistance. Insulin resist- anee may be one of the reasons for weight gain in VPA - treated patients.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2008年第1期53-54,共2页
Journal of Applied Clinical Pediatrics
关键词
丙戊酸钠
体质量增加
胰岛素抵抗
癫痫
sodium valproate
weight gain
insulin resistance
epilepsy
