摘要
目的研究复方丹参滴丸对过氧化氢(H2O2)损伤PC12细胞的保护作用,探讨复方丹参滴丸治疗缺血性脑血管病的作用机制。方法采用细胞培养和H2O2诱导细胞损伤的方法,观察复方丹参滴丸对PC12细胞的保护作用。结果复方丹参滴丸6.25,12.50,25.00μg.mL-1均可明显对抗100和500μmol.L-1H2O2引起的PC12细胞凋亡(P<0.01)。结论复方丹参滴丸可以促进PC12细胞的营养和增殖作用,并有抗H2O2诱导细胞凋亡作用。
Objective To study the protection of fufang danshen diwan on injured PC12 cells by H2O2 and mechanisms of which treating ischemic cerebrovascular disease . Methods Protection of fufang danshen diwan on injured PC12 cells caused by H202 was observed. Results 6.25,12.50 and 25.00μg·mL^-1 offufang danshen diwan significantly suppressed PC12 cells apoptosis induced by 100 and 500μg·mL^-1 H2O2 （P 〈 0.01 ）. Conclusion The results show thatfufang danzhen diwan can simulate the proliferation of PC12 cells and protect cell apoptosis induced by H2O2.
出处
《医药导报》
CAS
2008年第2期159-161,共3页
Herald of Medicine
