摘要
目的监测本地区泌尿生殖道感染支原体对抗菌药物的敏感性变化趋势,指导临床合理用药。方法对近3年分离鉴定的的泌尿生殖道感染解脲支原体(Uu)和人型支原体(Mh)株进行药敏检测,统计分析其药敏变化趋势。结果Uu对强力霉素、美满霉素和克拉霉素稳定保持较高的敏感性,对罗红霉素敏感率一直在较低水平。Mh对强力霉素、美满霉素和交沙霉素敏感率最高,稳定保持在75%以上。对克拉霉素、罗红霉素、阿奇霉素敏感率在10%以下。两种支原体对奎诺酮类药物敏感性均呈显著下降趋势。监测期间,对3～6种抗生素敏感的株数占总分离株的60%以上,对7种及以上药物敏感的株数所占比例呈下降趋势,而仅对1种或2种药物敏感的株数比例呈上升趋势。结论支原体对奎诺酮类药物的耐药性上升趋势明显,同时多重耐药株增多,支原体耐药性的监测结果是指导临床治疗用药的重要依据。
Objective To investigate changing trend of susceptibility of genital mycoplasma to common antimicrobial agents in Shenzhen City. Methods The in vitro activities of 9 antibiotics against U, urealyticum （Uu） and M. hominis （Mh） strains isolated from patients in 2004 - 2007 were determined and compared. Results A total of 2607 Uu and 60 Mh strain were examined. During the past 3 years, the susceptibility of Uu to doxyeyeline, minocyeline and elarythromyein was high, but its suscrptibility to roxithromycin was very low. Over 75% of Mh isolates were sensitive to doxycycline,minocycline and josamycin, but its suscrptibility to clarythromycin, roxithromyein, azitromvcin was less than 10% . Conclusion The tendency of resistance of Mycoplasma islates to quinolones isolates increased in the past 3 years. Multiple resistance to two or more antibiotics are frequent. Long - term monitreing of resistance Mycoplasma is important for guiding clinical treatment of Mycoplasm infection.
出处
《中国热带医学》
CAS
2008年第2期333-334,共2页
China Tropical Medicine
关键词
支原体
抗生素
敏感性
趋势
Mycoplasma
Antibiotics
Susceptibility
