摘要
目的总结进展期胃癌根治术后腹腔温热化疗的疗效。方法回顾在1990年代后收治的进展期胃癌根治术后患者,比较腹腔温热化疗组(治疗组)和常规静脉治疗组(对照组),治疗组采用腹腔温热化疗+常规静脉治疗,对照组采用常规静脉化疗,两组治疗方案及剂量均相同。分析两组患者化疗毒副作用、腹腔复发率和生存率。结果两组毒副作用差异无显著性;治疗组腹腔复发率低于对照组,治疗组3年生存率高于对照组,差异有显著性(P<0.05)。结论胃癌根治术后腹腔温热化疗可提高生存率,预防腹腔复发,改善患者的生存质量。
Objective To investigate the therapeutic efficacy of early hyperthermic intraperitoneal chemotherapy after radical operation in patients with advanced gastric cancer. Methods The therapeutic efficacy of hyperthermic intraperitoneal chemotherapy of a total of 278 patients with stage Ⅱ and Ⅲ gastric cancer between 1990 and 2003 was reviewed. Of these patients ,237 were treated with intravenous chemotherapy and early intraperitoneal chemotherapy（ trial group）, while the other 41 were treated with only intravenous chemotherapy（ control group）. The two groups were given the same dosage and the chemotherapy was repeated at 4-week intervals. A total of 6 cycles were given for all patients. The efficacy and side effects were watched and analysed. Results The 3-year survival rates of trial group and control group were 56.1% and 39.0% （ P 〈 0. 05 ） , and local relapse rates were 46.8% and 58.5% （ P 〈 0.05 ） respectively. The side effects of two groups showed no significant difference. Conclusions Hyperthermic intraperitoneal chemotherapy in patients with advanced gastric cancer after radical operation was found to be effective in improving the prognosis of the patients with advanced gastric cancer.
出处
《中国肿瘤临床与康复》
2007年第6期518-520,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
胃肿瘤
腹腔温热化疗
生存率
Stomach neoplasms
Hyperthermic intraperitoneal chemotherapy
