摘要
干扰素┐γ对哮喘患者抗原引起气道嗜酸性粒细胞浸润的影响ＥｆｅｃｔｏｆＩｎｔｅｒｆｅｒｏｎ┐ｇａｍｍａｏｎＡｎｔｉｇｅｎ┐ｉｎｄｕｃｅｄＥｏｓｉｎｏｐｈｉｌＩｎｆｉｌｔｒａｔｉｏｎｉｎｔｏｔｈｅＡｓｔｈｍａｔｉｃＡｉｒｗａｙＬｉＧｕｏｘｉｕＬｉｕＧｕａ...
To investigate whether human recombinant interferon gamma (hrIFN γ) is capable of inhibiting the antigen induced eosinophil infiltration into the airways of the patients with allergic bronchial asthma,ten atopic asthmatic subjects were underwent an initial bronchoscopy when the hrIFN γ plus dust mite were instilled into a subsegment of the lingula or right middle lobe and diluent plus dust mite were instilled into a subsegment of the opposite lung (middle lobe,or lingula).The second bronchoscopy was performed 24 h later,and bronchial mucosa from each treated sites were taken separately.Immunohistochemical technique was used to evaluate the presence of eosinophils and some subsets of T lymphocytes including CD4 +,CD8 + and CD25 + cells.Immunostaining revealed decreases in the numbers of total eosinophils (BMK 13 + cells, P<0 01), CD4 + lymphocytes (P<0 01) and CD25 + cells (P<0 05) from IFN γ treated biopsies compared with control biopsies. However,no difference was observed in the numbers of CD8 + cells.Locally administered hrIFN γ could prevent the antigen induced eosinophil recruitment into the asthmatic airways by inhibiting CD4 + T cell infiltration as well as T cell activation.These results suggest that hrIFN γ may be of value in obtaining clinical improvement in asthmatics.
出处
《广西科学》
CAS
1997年第2期150-154,共5页
Guangxi Sciences
基金
广西区科委自然科学基金
关键词
干扰素-Γ
嗜酸性粒细胞
哮喘
抗原
浸润
human recombinant interferon gamma(hrIFN γ),eosinophils,asthma
