摘要
原发性干燥综合征(PSS)的病因未明,其中可能涉及遗传因素。用序列特异性引物聚合酶链反应(PCR-SSP)法对70例PSS患者和136名正常人进行人类组织相容性抗原(HLA)-DRβ基因分型。发现PSS患者群体的HLA-DR3、DR52及DR2的基因频率明显高于正常对照组,而HLA-DR5及DR9的基因频率则相反,提示PSS的发病与DR3、DR52及DR2呈正相关;而和DR9、DR5呈负相关。2个PSS患者家族的姐妹与患者具有相同的遗传因素,且和PSS患者群体测定的正相关基因相一致。PSS患者的主要自身抗体(抗SSA抗体及抗SSB抗体)与HLA-DR52之间有明显的相关性,因而表明PSS的发病和遗传因素有关。
The pathogenesis of primary Sjogren syndrome (PSS) is unclear yet. In order to investigate the role of genetic factor playing in the mechanism of this disorder, we studied the HLA DR β gene distributed in 70 patients with PSS and 136 normal subjects by using PCR SSP technique. The results showed that the gene frequences of HLA DR 3、DR 52 and DR 2 in patients with PSS were significantly higher than that in normal controls. However, the gene frequencies of HLA DR 5 and DR 9 in PSS patiens were lower than that in the control group. There were the same genetic phenomena in the siblings of two PSS patients′ families. We also found the relationship between HLA DR 52 and the anti antibodies of SSA or SSB. Our results concluded that the genetic factor is involved in the pathogenesis of primary Sjogren syndrome.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1997年第6期398-401,共4页
Chinese Journal of Internal Medicine