摘要
目的:考察银黄制剂的药动学特征。方法:建立测定大鼠血浆中黄芩甙的高效液相色谱法(HPLC),并以银黄颗粒为代表进行药代动力学研究。结果:黄芩甙经直肠灌注比灌胃血药浓度高、消除速率慢;黄芩甙经灌胃会产生首过代谢作用,同时在用药后约600 min出现双峰现象;银黄颗粒中的黄芩甙受其它成分的影响不明显,在大鼠体内的药动学过程与单体黄芩甙基本一致。结论:用建立的HPLC法进行银黄颗粒的药代动力学研究,方法简单、准确、快速,并且获得的药代动学参数具有一定临床应用价值。
Aim:To understand the pharmacokinetic characteristics of Yinbuang preparations.Mehtods:A high performance liquid chromatographic (HPLC) method was established to determine the contents of baicalin in rats plasma after they were given Yinhuang granule by oral and rectum respectively.Results:The baicalin of rectal administration had higher plasma concentration and slower climination rate than that of oral administration,while the latter had first-pass metaholism and gave a second peak at about600min.Thie basicalin in Yinhuang granule was little affected by over compositions and its pharmacolineties was basionally conaistent with that of the monomer baicalin.Conclusion:The developed HPLC method is simple,accurate and quick for the pharmacukimetic study of Yinbuang granule.The obtained pharmacolinetic parameters are valuable for clinical application,
出处
《中兽医医药杂志》
2008年第1期17-19,共3页
Journal of Traditional Chinese Veterinary Medicine
基金
国家科技攻关计划子课题(2002BA518A04)