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曲美他嗪对慢性心力衰竭患者血浆脑钠肽水平及心功能的影响 被引量:9

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摘要 目的:分析曲美他嗪对慢性心力衰竭(心衰)患者血浆脑钠肽(BNP)水平和心功能的影响。方法:选择慢性心衰患者60例,随机分常规抗心衰组30例和曲美他嗪组30例。常规抗心衰组,应用常规抗心衰药物如血管紧张素转化酶抑制剂、利尿剂、洋地黄制剂、β受体阻制剂治疗。曲美他嗪组在常规抗心衰治疗基础上加用曲美他嗪。2组疗程均为3个月。另设正常对照组为健康者30例。治疗前后测所有对象的血浆BNP浓度,行超声心动图评价心脏收缩功能的改善情况。结果:经治疗后曲美他嗪组心衰疗效优于常规抗心衰组,血浆BNP下降率大于常规抗心衰组,曲美他嗪组左室射血分数较治疗前明显增加,也明显高于常规抗心衰组治疗后的水平。结论:在常规心衰治疗的基础上加用曲美他嗪能改善慢性充血性心衰患者的心脏收缩功能,同时能显著降低血浆BNP的水平量。
出处 《临床心血管病杂志》 CAS CSCD 北大核心 2007年第11期879-880,共2页 Journal of Clinical Cardiology
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参考文献7

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