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SHP-1基因与白血病/淋巴瘤

SHP-1 gene and leukemia/lymphoma
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摘要 SHP-1基因是近年来发现的抑癌基因,通过对下游信号蛋白分子磷酸酪氨酸脱磷酸化而终止、消弱细胞生长信号或激活凋亡信号负调控造血细胞的分化、发育和增殖。启动子甲基化是SHP-1基因沉默的主要机制,SHP-1表达降低及缺如与造血细胞的恶性转化及增殖优势表型有密切的关系,并与白血病/淋巴瘤的形成、侵袭性及预后相关。 SHP-1 is a tumor suppressor gene found in recent years. SHP-1 negatively modulates the differentiation, growth and proliferation of hematopoietic cells by dephosphorylating the downstream proteins, which subsequently either terminate or attenuate the activated growth signal or activate apoptosis pathway. Aberrant promoter methylation is the major/nechanism of SHP-1 gene silencing, The decreased levels of SHP-1 protein and mRNA were associated with the transformation and growth advantage of hematopoietic cells, and were related to the onset, aggression, and prognosis of leukemia/lymphoma.
作者 李英华 罗建民
机构地区 哈励逊国际和平医院血液科 河北医科大学第二医院血液科
出处 《国际病理科学与临床杂志》 CAS 2007年第6期507-510,共4页 Journal of International Pathology and Clinical Medicine
基金 河北省自然科学基金(C200500074) 衡水市科技局科学技术研究与发展计划项目(06020Z)~~
关键词 SHP-1 抑癌基因 基因沉默 甲基化 SHP-1 tumor suppressor gene gene silencing methylation
分类号 R733 [医药卫生—肿瘤]
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参考文献21

  • 1Wu C, Sun M, Liu L, et al. The function of the protein tyrosine phosphatase SHP-1 in cancer[J]. Gene, 2003, 306(13) : 1-12.
  • 2Zhang J, Somani A K, Siminovitch K A. Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling [ J ]. Semin Immunol, 2000, 12(4) : 361-378.
  • 3Samuel W, Douglas J H. Inhibitors of cytokine signal transduction [J]. J Biol Chem, 2004, 279(2) : 821-824.
  • 4Coggeshall K M, Nakamura K, Phee H. How do inhibitory phosphatases work? [J]. Mol Immunol, 2002, 39(9) :521-529.
  • 5Nishigaki K, Hanson C, Ohashi T, et al. Erythroblast transformation by the friend spleen focus-forming virus is associated with a block in erythropoietin-induced STATI phosphorylation and DNA binding and correlates with high expression of the hematopoietic phosphatase SHP-I[J]. J Virol, 2006, 80(12): 5678-5685.
  • 6黄定德,陈杞,韩玲,蔡建明,李百龙,傅志超,黄越承,林亚华,赵芳.SHP-1、SHP-2蛋白的酪氨酸磷酸化水平在γ射线诱发的白血病小鼠胸腺细胞中变化的研究[J].中华放射医学与防护杂志,2003,23(3):174-175. 被引量：3
  • 7Oka T, Yoshino T, Hayashi K, et al. Reduction of hematopoietic ceil-specific tyrosine phosphatase SHP-1 gene expression in natural killer cell lymphoma and various types of lymphomas/leukemias: combination analysis with cDNA expression array and tissue microarray[ J]. Am J Pathol, 2001, 159(4) : 1495-1505.
  • 8韩颖,罗建民,贾晓辉,王福旭,姚丽,杜行严.白血病患者造血细胞磷酸酶与半胱氨酸蛋白酶基因表达及其临床意义[J].中华内科杂志,2006,45(5):363-365. 被引量：18
  • 9Bruecher-Encke B, Griffin J D, Neel B G, et al. Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation [ J ]. Leukemia, 2001, 15(9) : 1424-1432.
  • 10Mulloy J C, Migone T S, Ross T M, et al. Human and simian Tcell leukemia viruses type 2 ( HTLV-2 and STLV-2pan-p) trans-form T cells independently of Jak/STAT activation [ J ]. J Virol, 1998, 72(5) : 4408-4412.

二级参考文献8

  • 1罗建民,刘泽林,郝洪岭,董作仁,王福旭,大野竜三.急性白血病细胞HCP基因的突变分析[J].临床血液学杂志,2004,17(5):271-273. 被引量：6
  • 2Uesugi Y, Fuse I, Toba K, et al. Involvement of SHP-1, a phosphotyrosine phosphatase, during myeloid cell differentiation in acute promyelocytic leukemia cell lines. Eur J Haematol, 1999, 62 :239-245.
  • 3Dong Q, Siminovitch KA, Fialkow L, et al. Negative regulation of myeloid cell proliferation and function by the SH2 domain-containing tyrosine phosphatase-1. J Immunol, 1999, 162 : 3220-3230.
  • 4Cascino I, Papoff G, Maria RD, et al. Fas/Apo-1 ( CD95 ) receptor lacking the intracytoplasmic signaling domain protects tomor cells from Fas-mediated apoptosis. J Immunol, 1996,156 : 13 - 17.
  • 5Kang KR, Kim CW. Regulation of chicken protein tyrosine phosphatase 1 and human protein tyrosine phosphatase 1B activity by casein kinase Ⅱ and p561ck-mediated phosphorylation. Exp Mol Med, 2000, 32:47-51.
  • 6Kozlowski M, Mlinacic-Rascan I, Feng GS. Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. J Exp Med, 1993, 178:2157-2163.
  • 7Soini Y, Paakko P. Apoptosis and expression of Caspases 3 ,6 and 8 in malignant non-Hodgkin's lymphomas. APMIS, 1999, 107:1043 -1050.
  • 8樊娟,徐功立,徐健,王春霞,马兰英.caspase3在细胞因子调节急性白血病细胞凋亡中的变化[J].中华血液学杂志,2000,21(6):305-308. 被引量：10

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国际病理科学与临床杂志
2007年 第6期

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