摘要
目的:评价术后序贯放化疗对中晚期胃癌的生存影响和不良反应.方法:收集我院2003-01/2005-12胃癌根治术后行序贯放化疗患者36例及对照单纯化疗患者32例,分析两组的1年和3年生存率,同时评价放化疗期间出现的血液学,肝肾功能及胃肠道等不良反应.结果:术后序贯放化疗组和单纯化疗组1年生存率分别为77%和61%,3年生存率分别为47%和25%(P=0.041),中位生存时间分别为40.0 mo和24.5 mo(P=0.038),治疗期间两组出现Ⅲ-Ⅳ级白细胞减少分别为11.1%和6.3%,Ⅲ-Ⅳ级恶心呕吐分别为8.3%和3.1%,但差异无统计学意义.结论:胃癌患者术后序贯放化疗较单纯化疗可提高1年和3年生存率,延长中位生存时间,不良反应可耐受.
AIM： To investigate the effect of postoperative sequence chemoradiotherapy compared with postoperative chemotherapy alone on survival of patients with advanced gastric cancer, and to evaluate the toxic effect.
METHODS： A total of 68 patients were collected from our hospital from January 2003 to December 2005. Thirty-six patients received sequence chemoradiotherapy following radical resection, and 32 patients received chemotherapy alone following radical resection. The 1- and 3-yr survival rate were evaluated, as well as the hematologic and gastrointestinal toxic effects, and liver and kidney function.
RESULTS： The 1- and 3-yr survival rate of the sequence chemoradiotherapy group was 77% and 47%, respectively, as compared with 61% and 25% in the chemotherapy only group （P = 0.041）.The median survival time was 40 mo compared with 24.5 mo in the control group （P = 0.038）. Grade Ⅲ-Ⅳ leukopenia occurred in 11.1% of the sequence chemoradiotherapy group compared with 6.3% in the control group. Grade Ⅲ-Ⅳ nausea and vomiting occurred in 8.3% compared with 3.1% in the control group. No statistic significant correlation was found in toxic effect.
CONCLUSION： Postoperative sequence chemoradiotherapy of gastric cancer improves the 1- and 3-yr survival rate significantly, and prolongs the median survival time compared with postoperative chemotherapy alone. The toxic effects are tolerable.
出处
《世界华人消化杂志》
CAS
北大核心
2007年第36期3856-3859,共4页
World Chinese Journal of Digestology
关键词
中晚期胃癌
序贯放化疗
OLF方案
生存率
Gastric cancer
Sequence chemoradiotherapy
OLF regimen
Survival rate
