摘要
目的:用无创性动态血压监测仪评价国产复方坎地沙坦酯片(坎地沙坦酯16 mg/氢氯噻嗪12.5 mg)对原发性高血压患者的降压疗效。方法:原发性高血压患者经过2周清洗期后,进入坎地沙坦酯片8 mg 单药治疗期,对4周后坐位血压未达标者(达标为血压<140/90 mmHg),进行24小时动态血压监测,以随机双盲、平行对照试验方法,分别服用复方坎地沙坦酯片(复方坎地沙坦酯组,28例)或16 mg 坎地沙坦酯片(坎地沙坦酯组,27例)治疗8周。比较两组服药前后24小时动态血压参数变化。观察组内与组间服药前后的不同时段的血压变化,谷峰比值及血压平滑指数。结果:共55例患者完成动态血压监测,两组基础指标比较无差异。复方坎地沙坦酯组与坎地沙坦酯组药后收缩压/舒张压/平均动脉压全日平均值(24小时)、日间平均值(6:00～22:00)、夜间平均值(22:00～6:00)均明显下降,与同组基线值比较均有极显著性差异(P<0.01)。组间比较,复方坎地沙坦酯组收缩压/舒张压/平均动脉压全日平均值(24小时)、日间平均值(6:00～22:00)、夜间平均值(22:00～6:00)的降低幅度与坎地沙坦酯组比较均有极显著性差异(P<0.01)。服药谷峰比值(SBP/DBP)复方坎地沙坦酯组分别为99.36%(19.16/19.28 mmHg)和87.36%(10.14/11.61 mmHg),复方坎地沙坦酯组分别为54.42%(7.30/13.41 mmHg)和64.86%(6.43/9.91 mmHg)。血压平滑指数(SBP/DBP)在复方坎地沙坦酯组为4.53/3.91,坎地沙坦酯组为1.29/1.52。结论:复方坎地沙坦酯片对原发性高血压患者有较好的降压作用,复方制剂比单药降压幅度大、持续时间长。动态血压平均下降幅度日间>全天>夜间,收缩压>舒张压。复方坎地沙坦酯控制血压更平稳。
Objectives ： To compare the antihypertensive efficacies of candesartan cilexetil 16 mg/HTCZ12. 5 mg with candesartan cilexetil 16mg after 8 weeks treatment by 2d-hour ambulatory blood pressure monitoring（ABPM）. Methods： A randomized, double-blind, parallel-group study of Can/HTCZ （group 1 ） versus Can （group 2） was conducted in 55 patients with mild-to-moderate essential hypertension whose target sitting diastolic BP was not achieved （ SeDBP 〈 90 mmHg）after 4 weeks treatment with 8 mg candesartan cilexetil once-daily were undergone ABPM. Changes of daytime and night-time diastolic （DBP） and systolic blood pressures （SBP） by ABPM were compared. Tough peak ratio （TPR）and smoothness index （SI） were calculated for each group. Results： The mean BP（SBP/DBP） at 24h,daytime and night-time by ABPM in group 1 （n = 28 ） decreased by 15.86 ± 8. 24/8.75 ± 6. 23 mmHg, 17.04 ± 9. 60/10.00 ± 6. 87 mmHg and 14.61 ± 9.92/7.64 ± 7. 57 mmHg ; and in group 2 （ n = 27 ） decreased by 5.15 ± 7.67/4. 44 ± 4.59 mmHg,6. 70 ± 7. 12/5.26 ± 4.49 mmHg and 4. 11 ± 10.78/3.52 ± 6. 47 mmHg respeetively. The T/P ratio of SBP and DBP were 99.36% （ 19. 16/19. 28 mmHg） and 87.36% （ 10. 14/11.61 mmHg）in group 1 ; and 4.42% （7.30/ 13.41 mmHg） and 64. 86% （6.43/9.91 mmHg）in group 2 respectively. Conclusion：Compared with Can 16 mg,the compound Can 16 mg and HCTZ 12. 5 mg presented the better effect to the pa- tients with essential hypertension, and the compound product could reduce the blood pressure in a greater degree with longer time. The everage ambulatory blood pressure reducing model was like day time 〉 whole day 〉 night time, SBP 〉 DBP. The compound product may decease the blood pressure in a smoother way.
出处
《中国循环杂志》
CSCD
北大核心
2007年第6期447-450,共4页
Chinese Circulation Journal
关键词
原发性高血压
复方坎地沙坦酯片
动态血压监测
谷峰比值
平滑指数
Essential hypertension
Compound candesartan cilexetil
Ambulatory blood pressure monitoring
T/P ratio
Smoothness index
