摘要
目的:研究绝经早期激素和中药治疗对认知记忆和生存质量的影响。方法:收集绝经早期妇女104例,随机分为激素组和中药组各52例,治疗1年,每3个月随访1次,由专人进行简易智能精神状态量表(MMSE)和绝经期生存质量量表评分。结果:激素组和中药组在治疗后6个月、9个月、12个月MMSE评分较治疗前均有显著性提高(P<0.05)。绝经期生存质量量表中的血管舒缩症状、心理状态、生理状态方面,二组在治疗后各时间点上均比治疗前有明显提高(P<0.05)。性生活方面,激素组用药6个月开始出现明显改善,而中药组用药12个月始有明显提高。结论:绝经早期低剂量激素替代疗法和中药治疗1年对改善认知记忆和提高生存质量均有效。
Objective：To study effect of hormone and Chinese Traditional Medicine treatment on cognition and memory and quality of life in the women at the early stage of menopause. Methods： A total of 104 perimenopausal women who had perimenopausal syndrome were enrolled in this trial. They were randomly assigned to hormone group（HG） and Chinese Traditional Medicine group（CG） and treated for 1 year. They came to visit every 3 months. Mini-mental state examination（MMSE） and perimenopausal daily life score were assessed by a special doctor. Results： Both HG and CG had improvement in MMSE after 6 months, 9 months and 12 months. The two groups had significantly benefit in vasomotor, physical and psychosocial domain after treatment. In the sexual domain, the HG got better after 6 months whereas the CG appeared effective after 12 months. Conclusion： HRT was effective in improving cognition and memory and quality of dailylife. So was the Chinese Traditional Medicine treatment.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2008年第1期26-31,共6页
Reproduction and Contraception
基金
国家十五攻关项目,项目编号:2004BA720A08
