摘要
目的:分析慢性心力衰竭治疗中血管紧张素转换酶抑制剂(ACEI)的使用情况,了解其应用现状及其与治疗指南之间的差距及产生差距的原因。方法:调查住院及门诊患者的病因、心功能分级(NYHA)、血压、心率、左室射血分数、有无用药禁忌证、ACEI的使用剂量和时间、停药或减量的原因等,将门诊和住院病例分别按年龄(≥65岁,<65岁)、性别(男、女)、血压(>140mmHg,≤140mmHg)、心率(≥90次/min,<90次/min)、左室射血分数(>40%及≤40%)、心功能(Ⅱ、Ⅲ、Ⅳ)、病因、合并症分组,分析比较ACEI使用率和使用剂量。结果:住院患者ACEI的使用率为79.2%,其中91.3%达到治疗指南要求的靶剂量;门诊患者ACEI总的使用率为60.1%,75.2%达到治疗指南要求的靶剂量;血压、性别、合并肾功能不全等因素对ACEI的使用有显著影响。结论:ACEI在慢性心力衰竭的治疗与治疗指南尚有一定差距。
Objective： To obtain the information of therapies with angiotensin converting enzyme inhibitor （ACEI） in patients with heart failure in our hospital. Methods： The followings were collected in the study including etiopathog.enisis, cardiac function, blood pressure, heart rate,left ventricular ejection fraction, contraindication, the dosage of ACEI and the reason of drug withdrawal or decrement. The patients were divided into groups according to age,gender,blood pressure, heart rate,left ventricular ejection fraction, cardiac function, etiopathogenisis and comphcation. The usage and dosage of ACEI in different groups were analysed. Results： The usage rate of ACEI was totally 79.2% in hospitalized patients. There were 91.3% of them arrived to target dose of ACEI. In outpatient cases the usage rate of ACEI was 60.6%, 75.2% of those arrived to the target dose of ACEI. There were significant effects of blood pressure,gender and combination with renal dysfunction on the usage of ACEI. Conclosion： There is still a great gap between optimal medical strategy and clinical practice in the management of chronic heart failure.
出处
《天津医药》
CAS
北大核心
2008年第1期29-31,共3页
Tianjin Medical Journal
基金
天津市科委重点资助项目(项目编号:033111311)
