摘要
目的:观察葡萄糖酸锌(ZnG)治疗急性脑出血的临床疗效及安全性。方法:脑出血患者60例,随机分为治疗组和对照组各30例,在常规相同综合治疗的基础上,治疗组给予ZnG20g(相当于锌20mg),进食后口服或鼻饲,tid,连续28d。采用中国脑卒中临床神经功能缺损程度评分量表(CSS)分别于治疗后第7,14,28天对2组患者进行神经功能缺损评分及疗效评定。结果:治疗28d,治疗组CSS由治疗前的(19.6±8.7)分下降到治疗后的(11.8±4.6)分(P<0.01);对照组CSS由治疗前的(20.5±9.6)分下降到治疗后的(15.4±6.3)分(P<0.05);2组治疗后比较差异有显著性(P<0.05)。治疗组未见ZnG不良反应。结论:ZnG能有效改善急性脑出血患者的神经功能缺损,未见明显不良反应。
OBJECtIVE To study the clinical efficacy and safety of zinc gluconate on acute intracerebral hemorrhage （AICH）. METHODS 60 patients with AICH were divided into treatment and control groups of 31） cases,in the same basis of comprehesive treatment, the treatment group received ZnG 20g（equivalent zinc 20 mg）, oral or nasal feeding after eating; three times daily for 28 days. Adopted Chinese stroke clinical neurologic impairment score scale[CSS], we have worked out the neurologic impairment score and efficacy assessment in the first 7, 14,28 days after treatment on two groups patients. RESULTS For 28 days, the treatment group CSS from （ 19, 6 ± 8.7） points down to the （ 11.8± 4. 6） （P〈0. 01 ） ; CSS of the control group from （20. 5 ±9. 6） points to （15.4 ± 6. 3） （P〈0.05） ; The difference was significant （P〈0. 1）5）. No ADR was found in the ZnG treatment group. CONCLUSION ZnG can improve the neurologic impairment symptoms of AICH,no adverse drug reactions,
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2008年第1期53-54,共2页
Chinese Journal of Hospital Pharmacy
关键词
葡萄糖酸锌
脑出血
神经功能缺损
zinc gluconate
acute intracerebral hemorrhage
neurologic impairmenht symptoms
