摘要
目的：探讨在乳腺不典型增生癌变过程中雌激素受体表达的变化及其意义。方法：用ＡＢＣ免疫组化法检测正常乳腺，乳腺囊性增生病不典型增生和乳腺癌细胞雌激素受体（ＥＲ）表达。结果：正常乳腺上皮细胞和乳腺囊性增生病上皮增生Ⅰ级者上皮细胞ＥＲ染色结果相似。不典型增生Ⅱ级ＥＲ表达明显增强，１０例均为阳性。１０例不典型增生Ⅲ级中４例强阳性、３例弱阳性、３例完全为阴性。４０例乳腺癌中２６例（６０％）ＥＲ阳性。结论：ＥＲ作为乳腺癌发生的促进因子在乳腺良性疾病经不典型增生癌变过程中起重要的刺激、激活作用。部分重度不典型增生细胞可能已发生ＥＲ表达抑制，与非雌激素依赖性乳腺癌的发生有关。
Objective: To investigate the changes of estrogen receptor (ER) expression in the canceration process of breast atypical hyperplasia and their significance. Methods: The changes of ER expression were determined in patients with breast cystic hyperplasia complicated with atypical hyperplasia and those with breast cancer and the healthy individuals with ABC immunohistochemistry. Results: ER staining showed that the epithelia from the healthy individuals and those from the patients with cystic hyperplasia complicated with epithelial proliferation were similarly stained. The ER expression in the epithelia from the patients with atypical hyperplasia grade II was significantly enhanced and all of the 10 cases were ER positive. Of the 10 cases of cystic hyperplasia complicated with atypical hyperplasia grade III, 4 were strongly positive, 3 weakly positive and 3 negative. 26 of the 40 cases of breast cancer (60%) were ER positive. Conclusion: ER, a factor promoting the occurrence of breast cancer, plays important roles of irritation and activation in the canceration process of breast atypical hyperplasia. The inhibition of ER expression might occur in part of the cases of severe atypical hyperplasia and it may be related to the occurrence of estrogen-independent breast cancer.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1997年第4期321-323,共3页
Journal of Third Military Medical University
关键词
雌激素
乳腺增生
乳腺肿瘤
estrogen receptor
atypical hyperplasia
breast
neoplasm
