摘要
目的:研究早期足量应用美托洛尔对急性心肌梗死的疗效及安全性。方法:将40例AMI患者随机分为治疗组和对照组,治疗组静脉缓慢注射美托洛尔15mg后予美托洛尔150-200mg/d口服;对照组按常规剂量给予美托洛尔25-50mg/d口服,其它治疗相同,两组治疗4周。比较两组治疗后QTcd、心律失常发生的种类、心肌耗氧指数、梗死后心绞痛、梗死延展的发生率和心功能的变化。结果:治疗组QTcd、室性心律失常发生率、心肌耗氧指数、梗死后心绞痛和梗死延展的发生率均低于对照组(P<0.05),心功能两组无显著性差异。结论:AMI患者早期足量使用美托洛尔可以从多方面获益,安全性高。
Objective： To investigate the curative effect and security of using enough metoprolol early for the patient with acute myocardial infarction （AMI）. Methods： 40 cases of AMI patients were randomly divided into the control group and the therapy group. The therapy group was treated with intravenous injection of metoprolol 15mg, and then with metoprolol tablets 150-200mg/d. The control group was treated with routine dosage of metopeolol tablets （25-50mg/d）. Other treatment methods were the same in two groups. After 4 weeks, the changes of QTcd, the kind of cardiac arrhythmia, oxygen consumption index, the incidence of postinfarction angina pectoris and infarct extension, and heart function were analyzed. Results： QTcd, oxygen consumption index, the incidence of ventricular arrhythmia, postinfarction angina pectoris and infarct extension of the therapy group were lower than control group （P〈0.05）. There was no significant difference between the two groups in terms of heart function. Conclusion： The application of enough metoprolol early for the AMI patients has high curative effect and security.
出处
《现代生物医学进展》
CAS
2008年第2期309-310,292,共3页
Progress in Modern Biomedicine
关键词
美托洛尔
急性心肌梗死
Metoprolol
Acute Myocardial Infarction
