摘要
目的通过观察硬膜外腔注射不同浓度乙醇对晚期癌痛患者的止痛效果和并发症以及对家兔神经组织损伤修复的作用,探讨安全有效的乙醇浓度及剂量。方法选用50%、75%及100%3种浓度的乙醇对晚期癌痛患者行硬膜外腔注射止痛及实验兔L2～3硬膜外腔注射,光镜、电镜观察对脊神经组织的影响。结果50%乙醇(A组)疗效欠佳,维持时间短,不能达到无痛,尚需补充止痛剂;100%乙醇(C组)止痛效果确切,但不良反应严重;75%乙醇(B组)浓度较为适宜,止痛效果确切,并发症少。动物实验表明,三种不同浓度乙醇对神经损伤程度依次为100%>75%>50%。结论硬膜外腔注射75%乙醇治疗对晚期恶性肿瘤患者的疼痛疗效满意,副作用少。
Objective To explore safety and validity of different concentration alcohol and dosage in removing pain and complication to advanced carcinoma patients. Methods 50% ,75 % , 100% alcohol were injected respectively into epidural cavity of advanced carcinoma patients group and lumbar nerves 2 - 3 of experimental rabbits group for removing pain. After injection, we observed effects of different concentration alcohol on spinal nerve tissue by light microscope and electron microscope. Results 50% alcohol group can not get good effect, last less time, inability of painless; 100% alcohol group can get good odynolysis effect,but have severely adverse effect. As for 75% alcohol group not only can relieve pain clearly but also get less complication. The animal experiment show different alcohol concentration have different extent nerve injury. The extent of nerve injury of injecting three different concentration alcohol followed as 100% 〉 75 % 〉 50%. Conclusions Injecting 75 % alcohol to cavitas epiduralis can get satisefied odynolysis effect and less complication for advanced carcinoma patients.
出处
《医学信息（手术学分册）》
2007年第12期1084-1086,共3页
Medical Information Operations Sciences Fascicule
关键词
肿瘤
止痛
乙醇
tumor
odynolysis
alcohol
