摘要
目的探讨碱性成纤维细胞生长因子(bFGF)、转化生长因子β1(TGF-β1)在椎间盘退变组织中的表达情况和意义。方法选取2004年至2006年手术切除的50例腰椎间盘突出症患者的退变椎间盘组织(病变组)及10例因外伤手术切除椎间盘的正常间盘组织(对照组)。采用免疫组化方法、酶联免疫吸附法(EHSA)检测标本中bFGF、TGF—β1的表达。结果病变组椎间盘组织bFGF、TGF-β1的表达明显高于对照组(P〈0.05)。结论bFGF、TGF-β1在椎间盘的退变过程中可能发挥重要作用。
Objective To explore the expression and signficance of basic fibroblast growth factor ( bFGF ) and transforming growth factor( TGF-β1 ) in intervertebral disc degeneration. Methods The expression of hFGF and TGF-β1 in 50 cases of lubar intervertebral disc protrusion undergoing operation between 2004-2006 ( lesion group) and 10 cases undergoing operation because of trauma (control group ) was measured by immunohistochemistry and ELISA. Results The expression of bFGF and TGF-β1 in lesion group was higher than that in control group(P 〈 0. 05 ). Condusion bFGF and TGF-β1 may play an important role in the degeneration of intervertebral disc.
出处
《中国综合临床》
北大核心
2008年第2期156-157,共2页
Clinical Medicine of China
关键词
椎间盘退变
碱性成纤维细胞生长因子
转化生长因子
Intervertebral discs degeneration
Basic fibroblast growth factor
Transforming growth factor