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脂蛋白相关磷脂酶A2与冠心病的相关性研究进展 被引量：11

Progress in Research into Association Between Lipoprotein-Associated Phospholipase A2 and Coronary Heart Disease
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摘要 血浆脂蛋白相关磷脂酶A2(LP-PLA2)由成熟的巨噬细胞和淋巴细胞合成和分泌,又称血小板活化因子乙酰水解酶(PAF-AH),在血浆中主要与低密度脂蛋白结合。近年来,越来越多研究表明在冠心病的发病机制及预防性治疗上,LP-PLA2是一个新的有待研究的因子,其在循环中的含量和活性与冠状动脉事件风险存在正相关,可能成为冠心病治疗的新靶点。 Lipoprotein-associated phospholipase A2 （LP-PLA2）, also named platelet-activating factor, synthesized and secreted by ripe macrophage and lymphocyte, which are transported in human plasma mainly bound together with low-density lipoprotein. Research in recent years indicates the necessity of studying LP-PLA2 as a new factor in pathogenesis and prophylactic treatment of coronary heart disease. There is a positive eorrelation with the risk of the incidence of coronary artery disease, and LP-PLA2 may be the new therapeutic target of coronary heart disease.
作者 何德化 李卫华
机构地区 福建医科大学附属厦门第一医院心内科
出处 《心血管病学进展》 CAS 2008年第1期57-60,共4页 Advances in Cardiovascular Diseases
关键词 脂蛋白相关性磷脂酶A2 冠心病 动脉粥样硬化 lipoprotein-associated phospholipase A2 coronary heart disease atherosclerosis
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献26

  • 1Six DA,Dennis EA. The expanding superfamily of phospholipase A2 enzymes: classification and characterization [ J ]. Biochim Biophys A cta, 2000,1488 (1-2) : 1-19.
  • 2陈莉延,梁标.磷脂酶A_2的研究进展[J].国外医学（生理病理科学与临床分册）,2000,20(6):473-476. 被引量：23
  • 3Hansson GK. Inflammation, atherosclerosis, and coronary aftery disease[ J]. N Engl J Med,2005,352:1685-1695.
  • 4Sanchez-Quesada JL, Benitez S, Ordonez-Llanos J. Electronegative low-density lipoprotein[ J ]. Curr Opin Lipidol,2004,15:329-335.
  • 5Benitez S,Benitez S, Villegas V,et al. Impaired binding affinity of electronegatire low-density lipoprotein (LDL) to the LDL receptor is related to nonesterifled fatty acids and lysophosphatidyleholine content [ J ]. Biochemistry. ,2004,43: 15863-15872.
  • 6Benitez S, Camacho M, Arcelus R, et al. Increased lysophosphatidylcholine and non-esterified fatty acid content in LDL induces chemokine release in endothelial cells. Relationship with electronegative LDL [ J ]. Atherosclerosis, 2004, 177 : 299-305.
  • 7Theihneier G,de Geest B,van Veldhoven PP,et al. HDL-assoeiated PAF-AH redu~~es endothelial adhesiveness in apoE-/-mice [ J ]. FASEB J, 2000, 14 : 2032- 2039.
  • 8Quarck R, de Geest B,Stengel D, et al. Adenovirus-mediated gene transfer of hu- man platelet-activating factor-acetylhy drolase prevents injury-induced neoinfima formation and reduces spontaneous atherosclerosis in apolipoprotein E deficient mice[ J]. Circulation ,2001,103 : 2495-2500.
  • 9Blankenberg S, Stengel D, Rupprecht H J, et al. Plasma PAF-acetylhydrolase in patients with coronary artery disease: results of a crosssectional analysis [ J]. J Lipid Res ,2003,44 : 1381-1386.
  • 10Kolodgie FD, Burke AP, Skorija KS, et al. Lipoprotein-associated phospholipase A2 protein expression in the natural progression of human coronary atherosclerosis[J ]. Arterloscler Thromb Vase Biol,2006:26( 11 ) :2523-2529.

二级参考文献20

  • 1马丽萍,秦永文,郑兴,吴弘,丁继军,赵仙先,郭品娥.高敏感C反应蛋白和淀粉样物质A与冠状动脉病变程度的关系[J].第二军医大学学报,2004,25(7):763-765. 被引量：4
  • 2Libby P,Ridker PM,Maseri A.Inflammation and atherosclerosis[J].Circulation,2002,105:1135-1143.
  • 3Danesh J,Wheeler JG,Hirschfield GM,et al.C reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease[J].N Engl J Med,2004,350:1387-1397.
  • 4Ridker PM,Stampfer MJ,Rifai N.Novel risk factors for systemic atherosclersis:a comprison of C reactive protein,fibrinogen,homocysteins,lipoprotein (a),and standard cholesterol screening as predictors of peripheral arterial disease[J].JAMA,2001,285:2481-2485.
  • 5Ridker PM,Rifai N,Stampfer M J,et al.Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men[J].Circulation,2000,101:1767-1772.
  • 6Ridker PM,Hennekens CH,Roitman Johnson B,et al.Plasma concentration of soluble intercellular adhesion molecule 1and risks of future myocardial infarction in apparently healthy men[J].Lancet,1998,351:88-92.
  • 7Packard CJ,O'Reilly DS,Caslake MJ,et al.Lipoprotein-associated phospholipase A2as an independent predictor of coronary heart disease.West of Scotland Coronary Prevention Study Group[J].NEnglJ Med,2000,343:1148-1155.
  • 8Koenig W,Khuseyinova N,Lowel H,et al.Lipoprotein-associated phospholipase A2 adds to risk prediction of incident coronary events by C reactive protein in apparently healthy middleaged men from the general population:results from the 14-year follow up of a large cohort from southern Germany[J].Circulation,2004,110:1903-1908.
  • 9Oei HH,van der Meer IM,Hofman A,et al.Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke:the Rotterdam Study[J].Circulation,2005,111:570-575.
  • 10Caslake MJ,Packard CJ,Suckling KE,et al.Lipoprotein-associated phospholipase A2,platelet activating factor acetyl hydrolase:a potential new risk factor for coronary artery dis ease[J].Atherosclerosis,2000,150:413-419.

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心血管病学进展
2008年 第1期

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