摘要
目的:评估阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者生活质量和认知功能状况,探讨其与多导睡眠监测图(PSG)主要指标的关系。方法:选择2006年7月至2007年4月在兰州大学第一医院就诊经PSG确诊的62例OSAHS患者和32例非OSAHS患者(对照组),用生活质量自评量表、简易智能精神状态量表、Epworth嗜睡量表(ESS)进行评估。结果:OSAHS组生活质量、认知功能评分均低于对照组(63.9±14.7/78.8±4.5、24.6±2.0/27.1±1.3,P均(0.001);生活质量与呼吸紊乱指数(AHI)、ESS呈负相关(r=-0.52、-0.39,P均<0.01),与平均血氧饱和度、最低血氧饱和度呈正相关(r=0.28、0.26,P均(0.05);认知功能与AHI和ESS呈负相关(r=-0.86、-0.51,P均(0.001),与平均血氧饱和度、最低血氧饱和度正相关(r=0.36、0.60,P均<0.01);生活质量与认知功能呈正相关(r=0.54,P(0.01)。结论:OSAHS患者中生活质量和认知功能明显下降,二者存在相关关系。
Objective： To assess the quality of life （QOL） and cognition function in patients with severe obstructive sleep apnea （ OSAHS ） , and to study the relationship between the QOL and severity of OSAHS, excessive daytime sleepiness （EDS ） , cognition disorders. Methods： Sixty-two patients with OSAHS and 32 non-OSAHS patients （ control group） which all diagnosed by polysomnography （ PSG） were chosen from The First Hospital of Lanzhou University, and they were assessed by QOL using the Short-Form 36 Health Survey questionnaire （ SF-36 ） , by EDS using the Epworth sleepiness scale （ ESS）, and for cognition disorders by mini-mental state examination （ MMSE） . The associations between the total score on the SF-36 and the baseline characteristics, PSG parameters, such as ESS score, and MMSE score were examined by simple regression analysis and stepwise multiple regression analysis. Results： The scores of SF-36 and MMSE in OSAHS group were significantly lower than the control group （ 63.9 ＋ 14. 7/78.8 ＋ 4. 5, 24. 6 ＋ 2.0/27. 1 ＋ 1.3, P 〈 0. 001 ） . In patients with OSAHS, the score of SF-36 was negatively correlated with apnea hyponea index （ AHI） and ESS （ r = -0. 52, -0. 39, P 〈0. 01 respectively, ） , and was positively correlated with mean level of SaO2 （ biSaO2, r = 0. 28, P 〈 0. 05 ） , and the lowest SaO2 （ LSaO2, r = 0. 26, P 〈 0. 05 ） . The score of MMSE in OSAHS group was negatively correlated with AHI （r= -0.86, P 〈0.001） and ESS （r= -0.51, P〈 0.001） , was positively correlated with MSaO2 （r=0.36, P〈0.01） and LSaO2 （r=0.60, P〈0.01） . The score of SF-36 was positively correlated with MMSE （ r = 0. 54, P 〈 0. 01 ） . Conclusion： There is an obvious decrease in OSAHS patients with quality of life and cognition function, which was correlated to frequently happened intermittent hypoxemia during the night.
出处
《中国心理卫生杂志》
CSSCI
CSCD
北大核心
2008年第2期133-136,共4页
Chinese Mental Health Journal
