摘要
目的探讨血浆脑钠肽(BNP)和内皮素1(ET-1)在心力衰竭(心衰)患者中的浓度变化及二者的相关性。方法采用微粒酶免疫法测定血浆BNP,采用酶联免疫吸附法测定血浆ET-1,心脏多普勒超声检查心脏左室射血分数(LVEF)和左室舒张末期内径(LVEDD)。结果心衰组血浆BNP及ET-1浓度明显高于正常对照组,均随心衰程度的加重而显著增加,且与LVEF呈明显负相关,与LVEDD呈正相关。心衰患者中血浆BNP与ET-1浓度变化呈正。结论血浆BNP、ET-1水平在心衰患者中明显升高,且与心衰的严重程度有明显相关性。
Objective To study the changes of plasma concentration of BNP and ET-1 in patients with congestive heart failure and the correlation between them. Methods Plasma concentration of BNP were measured by MEIA and that of ET-1 by EHSA. LVEF and LVEDD were examined by Doppler echocardio graphic. Results The plasma BNP and ET-1 level in patient group was significantly higher than that of the control group, and increased with the severity of heart failure. Plasma BNP and ET-1 correlated positively with LVEDD,and had a negative correlation with LVEF. The concentration of BNP correlated positively with the concentration of ET-1. Condusion The plasma concentration of BNP and ET-1 increases significantly in patients with heart failure and has obvious correlations with the severity of heart failure.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2008年第1期105-106,共2页
Journal of China Medical University
关键词
利钠肽
脑
内皮素1
心力衰竭
natriuretic peptide, brain
endothelin- 1
heart failure, congestive
