摘要
背景与目的:探讨Ras相似蛋白C(Ras homologue C,RhoC)和CD44剪接变异体v6(CD44splice variant V6,CD44v6)在胃癌中的表达及其与临床病理因素之间的关系。材料与方法:采用免疫组化SP法检测97例胃癌组织中RhoC和CD44v6的表达情况。结果:97例胃癌组织中RhoC和CD44v6阳性率分别为77.31%(75/97)、83.50%(81/97),两者表达存在相关性(P<0.05)。RhoC和CD44v6表达均与胃癌的浸润深度和肿瘤分期有关(P<0.05),且淋巴结转移组RhoC表达显著高于无淋巴结转移组(P<0.05)。结论:RhoC和CD44v6蛋白的过量表达是胃癌的发生发展中的频发事件,可以作为判断预后的指标之一。
BACKGROUND AND AIM: To investigate the expressions of RhoC and CD44v6 proteins in gastric carcinoma (GC) and their relationship to clinicopathological factors. MATERLALS AND METHODS: Immunohistochemi staining SP method was used to evaluate the expressions of RhoC and CD44v6 in 97 cases of GC. RKSULTS: 75(77.31% ) and 81 (83.50%) of 97 cases showed overexpressions for RhoC and CD44v6, respectively. There was a significant correlation between the overexpression of RhoC and CD44v6 (P 〈 0.05) The expressions of RhoC and CD44v6 in GC were significantly associated with the depth of tumor invasion and TNM staging(P〈0.05) Moreover, the RhoC overexpression was associated with lymph node metastasis(P 〈 0.05). CONCLUSION: Overexpressions of RhoC and CD44v6 proteins are frequent events in GC. Measurement of these protein expressions might be used as a prognostic indicator for GC.
出处
《癌变.畸变.突变》
CAS
CSCD
2008年第1期60-63,共4页
Carcinogenesis,Teratogenesis & Mutagenesis
基金
安徽省教育厅自然科学研究项目(2005kj378zc)
关键词
胃癌
RHOC
CD44V6
侵袭
免疫组化
gastric carcinoma
neoplasm
RhoC
CD44v6
invasion
immunohistochemistry