摘要
目的了解血浆前列环素在肝硬化门脉高压性胃病发病中的作用。方法应用特异性放射免疫分析法测定49例肝硬化门脉高压性胃病患者及30例正常对照者血浆前列环素水平。结果49例肝硬化门脉高压性胃病患者前列环素水平(137.31±61.82)pg/ml明显高于对照组(89.6±22.6)pg/ml,(t=1.684,P<0.05)。其中门脉高压性胃病轻、中度患者与对照组比较,均有明显差异(t=1.725,t=1.853,P<0.05),门脉高压性胃病重度患者与对照组比较,差异更明显(t=2.117,P<0.025)。但门脉高压性胃病各级间比较均无明显差异(P>0.05)。结论肝硬化门脉高压性胃病患者血浆前列环素明显升高,作为具有扩血管作用的炎性介质,在门脉高压性胃病发病中起重要作用。
Objective To evaluate the role of plasma prostaglandin I2 （ PGI2 ） in the development portal hypertensive gastropathy （PHG） in patients with liver eirrbesis. Methods Plasma prostaglandin I2 eoneentration was measured by radioimmunoassay in 49 patients with PHG and 30 healthy eontrols. Results Plasma PGI2 levels were signifieanfly increased in patients with mild.middle and severe PHG eompared to healthy eontrols（ 137. 31 ± 61.82 ）pg/ml VS （89. 6 ± 22. 6）pg/ml, t = 1. 684,P 〈 0. 05）. Conclusion The level of plasma PGI2 was shown to be increased in eirrhotie patients aeeompany PHG, Supporting that its syrttbesis by blood vessels of systemie eireulation is enhaneed. PGI2 as an inflammatory medium, damages the gastrie mueosa by expanding vessels in PHG.
出处
《临床肝胆病杂志》
CAS
2008年第1期34-35,共2页
Journal of Clinical Hepatology
关键词
肝硬化
门脉高压性胃病
前列环素
放射免疫分析法
liver eirrhosis
portal hypertensive gastropathy
Prostaglandin I2
radioimmunoassay
