摘要
目的：研究自由基与心理应激法诱导的IBS大鼠模型的关系及宁肠汤对自由基的调节作用。方法：以慢性束缚应激＋夹尾刺激作为心理应激原诱导IBS大鼠模型。测定模型大鼠MDA、SOD、T-AOC的含量,观察宁肠汤对IBS大鼠抗自由基氧化能力的调节作用。结果：慢性束缚应激＋夹尾刺激诱导的IBS大鼠抗氧化能力降低,血清MDA含量升高,SOD、T-AOC活性降低（P〈0.05-0.01）。而宁肠汤能降低IBS大鼠MDA含量,升高SOD、T-AOC活性（P〈0.01）。结论：心理应激致IBS大鼠抗氧化能力低下,自由基代谢产物储积,宁肠汤可以提高IBS大鼠的抗氧化能力,减少自由基代谢产物储积和其对组织细胞的损伤。
Objective ：To investigate the regutation of Ning Chang Decoction on free radical of stressed IBS rats. Methods ：The stressed IBS rat model Was made by chronic bandaged - stress and inserting the end. We determined the content of SOD, MDA, W - AOC of stressed IBS rats. The regulation of Ning Chang Decoction were observed. Results ： Stress increased the contents of serum MDA and decreased the contents of setum SOD,T - AOC（ P 〈 0.01 ）. While Ning Chang Decoction Could decrease the contents of serum MDA and strengthen the activity of SOD,T -rAOC of stressed IBS rats（ P 〈 0. 05 - 0. 01 ）. Conclusion ： Ning Chang Decoction could increase the antioxidation capacitY of stressed IBS rats.
出处
《中华中医药学刊》
CAS
2008年第2期323-325,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省中医药科技计划项目(2004Y009)
关键词
应激肠易激综合征
自由基
stress
irritable bowel syndrome
free radical
