摘要
目的通过检测fascin在正常子宫内膜、子宫内膜增生症及子宫内膜样腺癌中的表达,探讨其临床意义。方法应用链霉菌抗生物素蛋白-过氧化物酶连接(SP)法检测46例子宫内膜样腺癌、19例子宫内膜增生症以及17例正常子宫内膜组织中fascin的表达水平,并将结果进行比较。结果fascin在子宫内膜样腺癌中的表达率(71.74%)明显高于子宫内膜增生症组(15.79%)及正常内膜组(5.88%),三者之间比较差异有显著性(P<0.01);子宫内膜增生症患者子宫内膜组织与正常内膜组相比较,fascin阳性率虽有所增高,但差异无显著性(P>0.05);在子宫内膜增生症中,虽然复杂型增生及不典型增生中fascin的阳性表达率高于单纯型增生,但两者比较差异无显著性(P>0.05)。fascin在子宫内膜样腺癌不同临床分期中的阳性表达率分别为:Ⅰ期、Ⅱ期54.55%,Ⅲ期、Ⅳ期87.50%;在各组织学分级中fascin的阳性表达率分别为:高分化50.00%,中分化72.22%,低分化92.86%;在淋巴结转移组中的阳性表达率为89.47%,在无淋巴结转移组为59.26%,各组之间比较差异均具有显著性(P<0.05)。结论fascin的表达与子宫内膜样腺癌的发生、发展密切相关,可以为子宫内膜病变的良、恶性分析及判断肿瘤的生物学行为提供理论依据。
[Objective] The aim of this study was to investigate the expression of fascin in normal endometrium, endometrial hyperplasia and endometrioid adenocarcinoma tissues and to evaluate their clinical significance. [Methods] The expression of fascin was determine in 46 patients with endometrioid adenocarcinoma, 19 of endometrial hyperplasia and 17 of normal endometrium by immunohistochemistry of streptavidin-peroxidase （SP） technique, then these values were compare among each other. [Results] The positive rate of fascin in endometrioid adenocareinoma （71.74%） was higher than that in endometrial hyperplasia （15.79%） and normal endometrium tissues （5.88%）, there was significant difference between them （P 〈0.01）. The positive rate in endometrial hyperplasia was higher than normal endometrium, but without significant difference （P 〉0.05）. Although in the endometrial hyperplasia group, the expression of fascin in complex hyperplasia and atypical proliferation was higher than in simple hyperplasia, it didn＇t show significant difference between each other （P 〉0.05）. In endometrioid adenocarcinoma, the positive expression of fascin significantly increased with clinical phase（ Ⅰ,Ⅱ ： 54.55%,Ⅲ,Ⅳ：87.50%）, grade of cellular differentiation （G1： 50.00%, G2：72.22%, G3： 92.86%） and lymphatic metastasis （with： 89.47%, without： 59.26%） （P 〈0.05）. [Conclusions] The expression of fascin is correlated to the incidence, invasion and metastasis of endometrioid adenocarcinoma and it may provide theoretical evidence for identification between benign diseases and carcinoma of endometrium, it is also helpful for evaluating the behaviour of endometrioid adenocarcinoma.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2008年第2期198-201,共4页
China Journal of Modern Medicine
