摘要
目的:探讨舒筋汤熏洗加局部被动功能锻炼治疗膝骨性关节炎的作用和机理。方法:将65只新西兰兔,随机分为正常对照组15只和造模组50只。造模组造模成功后,随机分为热水熏洗组、舒筋汤熏洗组及舒筋汤熏洗加被动功能锻炼组,分别予热水熏洗、舒筋汤熏洗及舒筋汤熏洗加被动功能锻炼的治疗,正常对照组常规饲养。各组动物于治疗第14天、28天、56天分批处死,测量右后肢膝关节活动度(ROM)、心脏穿刺取血检测超氧化物歧化酶(SOD)和丙二醛(MDA),并行膝关节软骨组织的组织形态学观察。结果:舒筋汤熏洗加被动功能锻炼组和舒筋汤熏洗组ROM、SOD水平始终高于同时间段的热水熏洗组,而MDA水平始终低于同时间段的热水熏洗组,组间比较有显著性差异(P<0.01);舒筋汤熏洗加被动功能锻炼组和舒筋汤熏洗组比较,ROM、SOD水平始终高于舒筋汤熏洗组,MDA始终低于舒筋汤熏洗组(P<0.01)。结论:舒筋汤熏洗加被动功能锻炼组和舒筋汤熏洗组膝关节软骨组织修复情况较热水熏洗组好,该三组中舒筋汤熏洗加被动功能锻炼组膝关节软骨组织修复恢复情况最好。
Objective： To observe the range of motion, changes of oxygen free radical and the pathological changes of interarticular cartilage in rabbit models with experimental knee osteoarthritis before and after treatment for investigation of the effect and mechanism of fumigation therapy with Shujin decoction plus passive functional exercise in the treatment of knee osteoarthritis. Methods： Sixty five New Zealand rabbits were randomly assigned to two groups： 15 in control group and 50 in model group. After modeling, the model group was further divided into three subgroups： hot water fumigation group, Shujin decoction fumigation group and Shujin decoction fumigation plus passive functional exercise group, and treatments were given accordingly. Experimental rabbits in control group were fed routinely. The experimental rabbits in each group were batch sacrificed at the end of 14, 28, and 56 days after the treatment started. The range of motion （ROM） of the right stifle joint was measured. Detection was performed for the superoxide dismutase （SOD） and malondialdehyde （MDA） of blood samples obtained by cardiac puncture. The histomorphology of articular cartilage tissue in the knee was also observed. Results： The ROM, SOD and MDA in the Shujin decoction fumigation group and the Shujin decoction fumigation added with passive functional exercise group were consistently greater than those in the hot water fumigation group of the same batch, with a significant difference （P 〈 0.01） in MDA observed. The Shufin decoction fumigation plus passive functional exercise group had greater ROM and SOD but lesser MDA, compared with the Shujin decoction fumigation group（P 〈 0.01） . The pathologic observation showed that the repair of articular cartilage tissue appeared to be best in the Shujin decoction fumigation plus passive functional exercise group, moderate in the Shujin decoction fumigation group and mild in the hot water fumigation group. Conclusions： In the treatment of experimental rabbits with knee osteoarthritis, both Shujin decoction fumigation therapy and Shujin decoction combined with passive functional exercise therapy can remarkably increase SOD content and decrease MDA content in serum, and promote the reparation of articular cartilage injury in the knee.
出处
《广西中医药》
2008年第1期42-46,共5页
Guangxi Journal of Traditional Chinese Medicine
基金
广西卫生厅资助课题(Q96002)
广西中医学院资助课题(Y200346)
关键词
骨性关节炎
舒筋汤
功能锻炼
中医药疗法
Osteoarthritis
Shujin Decoction
functional exercise
Traditional Chinese medicine
