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肝再生磷酸酶-3与肿瘤 被引量：1

Phosphatase of regenerating liver-3 and tumor
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摘要 肝再生磷酸酶-3（PRL-3）是最新发现的与肿瘤转移相关的蛋白质酪氨酸磷酸酶（PTP），较多证据表明，PRL-3在结直肠癌、胃癌、乳腺癌、卵巢癌等表达明显升高，其表达异常与肿瘤的浸润和转移密切相关，可能成为抗肿瘤浸润和肿瘤治疗的一个新靶点。 Phosphatase of regenerating liver-3 （PRL-3 ） is a newly identified protein tyrosine phosphatase（PTP） associated with tumor metastasis. Many evidences indicate that PRL-3 expression is obviously high in such diseases as eoloreetal cancer, gastric cancer, breast cancer, ovarian cancer, etc. The abnormality of its expression closely correlates with tumor invasion and metastasis. It might be a novel antieaneer target for antiinvasive cancer therapy.
作者 郝儒田(综述) 张筱骅(审校) 潘贻飞(审校)
机构地区 温州医学院附属第一医院肿瘤外科
出处 《国际肿瘤学杂志》 CAS 2008年第1期53-56,共4页 Journal of International Oncology
关键词 肝再生磷酸酶-3 肿瘤 蛋白质酪氨酸磷酸酶 Phosphatase of regenerating liver-3 Neoplasms Protein tyrosine phosphatase
分类号 R730.1 [医药卫生—肿瘤]
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参考文献20

  • 1Zeng Q, Hong W, Tan YH. Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. Biochem Biophys Res Commun, 1998, 244 (2) :421-427.
  • 2Wu X, Zeng H, Zhang X, et al. Phosphatase of regenerating liver-3 promotes motility and metastasis of mouse melanoma cells. Am J Pathol, 2004, 164(6) :2039-2054.
  • 3Matter WF, Estridge T, Zhang C, et al. Role of PRL-3, a human muscle-specific tyrosine phosphatase, in angiotensin-Ⅱ signaling. Biochem Biophys Res Commun, 2001, 283(5):1061-1068.
  • 4Polato F, Codegoni A, Fruscio R, et al. PRL-3 phosphatase is implicated in ovarian cancer growth. Clin Cancer Res, 2005, 11 (19):6835-6839.
  • 5Kato H, Semb S, Miskad UA, et al. High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal, a predictive molecular marker of metachronous liver and lungmetastases. Clin Cancer Res, 2004, 10(21):7318-7328.
  • 6Guo K, Li J, Tang JP, et al. Catalytic domain of PRL-3 plays an essential role in tumor metastasis, formation of PRL-3 tumors inside the blood vessels. Cancer Biol Ther, 2004, 3(10):945-951.
  • 7Parker BS, Argani P, Cook BP, et al. Alterations in vascular gene expression in invasive breast carcinoma. Cancer Res, 2004, 64 ( 23 ):7857-7866.
  • 8Saha S, Bardelli A, Buckhaults P, et al. A phosphatase associated with metastasis of colorectal cancer. Science, 2001, 294 (5545):1343-1346.
  • 9Guo K, Li J, Wang H, et al. PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo. Cancer Res, 2006, 66 (19) :9625-9635.
  • 10Wang H, Quah SY, Dong JM, et al. PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal transition. Cancer Res, 2007, 67 (7):2922-2926.

同被引文献10

  • 1Zeng Q,Hong W,Tan YH,et al. Mouse PBL-2 and PBL-3 ,two potentially prenylated protein tyrosine phosphataseshomologous [ J ]. Biochemistry Biophys Res Commun, 1998,244 (2) :421-427.
  • 2Guo K ,Li J,Tang JP,et al. Catalytic domain of PRL-3 plays an essential role in tumor metastasis, formation of PRL-3 tumors in side the blood vessels[ J]. Cancer Biol Ther,2004,3 (10) :945-951.
  • 3Parker BS, Argani P, Cook BP, et al. Alterations in vascular gene Expression in invasive breast carcinoma[ J ]. Cancer Res,2004,64 ( 23 ) : 7857 -7866.
  • 4Saha S, Bardelli A, Buckhaults P, et al. A phosphatase associated With metastasis of colorectal cancer [ J ]. Science, 2001,294 ( 5545 ) : 1343- 1346.
  • 5Guo K, Li J, Wang H, et al. PRL-3 initiates' tumor angiogenesis by recruiting endothelial ceils in vitro and in vivo[ J]. Cancer Res,2006,66 ( 19 ) :9625-9635.
  • 6Wang H, Quah SY, Dong JM, et al. PRL-3 down-regulates PTEN expression and signals through P13K to promote epithelial-m esenchymal transition [ J ]. Cancer Res,2007,67 (7) :2922-2926.
  • 7Peng L,Jin G, Wang L, et al. Identification of integrin alphal as an interacting protein of protein tyrosine phosphatase PRL-3 [ J ]. Biochem Biophys ires Commun ,2006,342( 1) : 179-183.
  • 8Fiordalisi JJ, Keller PJ, Cox AD. PRL tyrosine phosphatases regulate rho family GT Pase to pormote invasion and mntility [ J ]. Cancer Res,2006,66(6) :3153-3161.
  • 9钱立平,范钰,陈坚,林庚金.RNAi沉默PRL-3基因对大肠癌细胞侵袭的抑制[J].世界华人消化杂志,2008,16(7):767-770. 被引量：6
  • 10王传泰,钱军.黏着斑激酶与结直肠癌的关系[J].中华全科医学,2010,8(3):362-363. 被引量：1

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国际肿瘤学杂志
2008年 第1期

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