期刊文献+

肾移植患者全血他克莫司浓度监测结果分析 被引量:6

Analysis of Blood Tacrolimus Concentrations in Renal Transplant Recipients
下载PDF
导出
摘要 目的:探讨肾移植患者全血他克莫司浓度的治疗窗及对血常规和肝肾功能的影响。方法:MEIA法监测全血他克莫司谷浓度。对近4年来390例次肾移植患者全血他克莫司浓度,及他克莫司对血常规和肝肾功能的影响进行分析。结果:390例次全血他克莫司浓度中377例次(80.8%)在3~15μg·L^(-1)的范围内。移植后6个月内,全血他克莫司浓度差异较大。随着移植时间延长,全血他克莫司浓度逐步降低。在治疗剂量内,他克莫司对肾移植受者的血常规和肝肾功能无明显影响。结论:全血他克莫司谷浓度的治疗窗:术后1~3月为5~15·L^(-1),第4~6月为5~10·L^(-1),>6个月为3~10·L^(-1)。他克莫司对肾移植受者的血常规和肝肾功能无明显影响。 Objective : To investigate the therapeutic range of tacrolimus and effects of tacrolimus on liver and renal functions and blood routine in renal transplant recipients. Method: The whole blood tacrolimus concentration was measured by micro-particle enzyme immunoassay (MEIA). Blood tacrolimus concentrations in 390 cases of renal transplant recipients were analyzed. The effects of tacrolimus on liver and renal function and blood routine were also studied. Result: The blood tacrolimus concentrations in 377 of 390 cases were within the range from 3 to 15 μg·L^-1. Their blood tacrolimus concentration differed greatly in renal transplant recipients within 6 months after transplantation. Their blood tacrolimus concentration was gradually decreased as time went on. Tacrolimus with therapeutic dosage had no effects on liver and renal function and blood routine. Conclusion: The therapeutic ranges of tacrolimus with MEIA were as follows: 5 to 15 μg·L^-1within 3 months after transplantation, 5 to 10 μg·L^-1 between 4 to 6 months after transplantation ,3 to 10μg·L^-1 6 months after transplantation, The administration of tacrolimus had no effects on the liver and renal function and blood routine in renal transplant recipients.
出处 《药物流行病学杂志》 CAS 2008年第1期17-20,共4页 Chinese Journal of Pharmacoepidemiology
基金 湖北省卫生厅科研基金(2007JX3B38)
关键词 肾移植 他克莫司 血浓度 肝肾功能 血常规 Renal transplantation Tacrolimus Blood concentration Liver and renal function Blood route
  • 相关文献

参考文献9

  • 1First MR. Tacrolimus based immunosuppression [ J]. J Nephrol, 2004,17 ( Suppl 8 ) :525-531.
  • 2邱实,刘龙,杨宏伟,郭时英,李昕,范连慧,曹志强,何城,向军.不同群体肾移植患者他克莫司临床应用初步探讨[J].中国药师,2005,8(11):938-940. 被引量:3
  • 3Christian U, Strom T, Zhang YL, et al. Active drug transport of immunosuppressants : new insights for pharmacokinetics and pharmacodynamics [J]. Ther Drug Monit, 2006,28 (1) :39-44 .
  • 4徐新军,张正行,刘皋林.新型免疫抑剂他克莫司药物动力学研究进展[J].国外医药(合成药.生化药.制剂分册),2001,22(2):93-96. 被引量:10
  • 5Venkataramanan R, Swaminathan A, Prasad T, et al. Clinical pharmacokinetics of tacrolimus [ J ] . Clin Pharmacokinet, 1995,29 (6) :404-430.
  • 6Brunet M. Pou L, Torra M, et al. Comparative analysis of tacrolimus ( FKS06 ) in whole blood in liver transplant recipient by PRO TRAC enzyme-linked immunosorbent assay and micropartical immunoassay IMX methods [ J ]. Ther Drug Monit, 1996,18 (6) : 706-709.
  • 7Martins L, Ventura A, Branco A, et al. Cyclosporine versus tacrolimus in kidney transplantation, are there differences in nephrotoxicity ? [ J ] Transplant Proc, 2004,36 ( 4 ) : 877-879.
  • 8Boratynska M, Banasik M, Patrzalek D, et al. Conversion from cyclosporine-based immunosuppression to tacrolimus/ mycophenolate mofetil in patients with refractory and ongoing acute renal allograft rejection [J]. Ann Transplant,2006,11 (2) :51-56.
  • 9Martins L, Henriques AC, Dias L, et al. Conversion to tacrolimus in caseproblem kindey transplant recipients under cyclosporine-based immunosuppression [ J ]. Transplant Proc, 2000, 32 (8) : 2636- 2638.

二级参考文献8

  • 1Pirsch JD,Miller J,Deierhoi MH,et al.A comparison of tacrolimus(FK506)and cyclosporine for immunosuppression after cadaveric renal transplantation [J].Transplantation,1997,63:977-983.
  • 2Hutton J.The economics of immunosuppression in renal transplantation:a review of recent literature[J].Transplant Proc,1999,31:1328-1332.
  • 3Schleibner S,Krauss M,Wagner K et al,Fk-506 versus cyclosporin in the prevention of renal allograft rejection.European pilot study:six-week results[J].Transpl Int,1995,8:86-90.
  • 4Kihira K,Kadoyama M,Miyake K,et al.Pharmacokinetic behavior of cyclosporine A in liver dysfunction[J].Hiroshima J Med Sci,1994,43(4):175-178.
  • 5European Tacrolimus Multicentre Renal Study Group.Multicentre randomized trial comparing tacrolimus(FK506) and cyclosporin in the prevention of renal allograft rejection:a report of the European Tacrolimus Multicentre Renal Study Group[J].Transplantation,1997,64:436-443.
  • 6Mi-Jeong Lee,Robert M. Straubinger,William J. Jusko. Physicochemical, Pharmacokinetic and Pharmacodynamic Evaluation of Liposomal Tacrolimus (FK 506) in Rats[J] 1995,Pharmaceutical Research(7):1055~1059
  • 7邱实,刘龙,赵黎明,段万玲,夏冬亚,蒋玲,向军.他克莫司和环孢素A对肾移植术后患者肝功能影响的临床比较观察[J].中华器官移植杂志,2001,22(6):364-365. 被引量:13
  • 8何强,陈江华,王逸民,吴建永,张建国,彭文翰.两种包含他克莫司的免疫抑制方案在肾移植中的应用体会[J].中华器官移植杂志,2002,23(5):284-285. 被引量:10

共引文献11

同被引文献34

引证文献6

二级引证文献18

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部