摘要
代谢组学是后基因时代出现的一门新兴"组学"学科,它用反映整体的代谢物图直接认识生理和生化状态,能提供区别于其他"组学"的大量信息。代谢组学已经用于评价实验动物模型和外源物产生的一系列代谢过程和作用机制、靶器官的效应、组织损伤。其应用涵盖疾病诊断、新药研究开发、模型识别和确证研究、新生物标志物的发现、新药筛选、安全性实验和作用机制以及中医药研究等方面。
Metabonomics is a new ＂-omics＂ science in post-gene time. Metabonomics can directly understand the physiological and biochemical situation by its ＂metabolome profile＂ as a whole, and therefore can provide various information that differs from other ＂-omics＂. Metabonomics has been applied in disease diagnosis, assessment of animal models, screening of new drugs, evaluation of drug safety, discovery of new biomarkers of toxicity, as web as research of traditional Chinese medicine.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2007年第6期712-718,共7页
Acta Academiae Medicinae Sinicae
关键词
代谢组学
疾病研究
药物开发
药物作用机制
药物安全性
中医药
metabonomics
disease research
pharmaceutical development
drug action mechanism
drug safety
traditional Chinese medicine
