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β_1整合素在糖尿病大鼠肾脏的表达及阿托伐他汀的影响 被引量：4

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摘要 目的:观察糖尿病大鼠肾脏氧化应激水平和β1整合素的表达及阿托伐他汀的影响。方法:制备糖尿病大鼠模型,随机将动物分为糖尿病组和治疗组,另设对照组,治疗组给予阿托伐他汀20mg/(kg·d)。8周后,检测各组尿白蛋白量、肌酐清除率、血糖、血脂、肾质量/体质量;免疫组化法检测肾小球β1整合素的表达;比色法检测肾脏丙二醛、总抗氧化能力水平;光镜下观察肾组织病理改变。结果:糖尿病组β1整合素比对照组明显增强,氧化应激水平明显异常;治疗组较糖尿病组β1整合素表达明显降低,氧化应激水平显著改善,尿白蛋白量及肾组织病理变化亦改善,血脂、血糖无显著变化。结论:阿托伐他汀可以减少糖尿病大鼠尿白蛋白量,改善肾脏病理变化,可能部分地通过抗氧化应激、下调肾脏β1整合素的表达实现。
作者 张慧敏 贾汝汉 杨定平 刘红燕 丁国华
机构地区 武汉大学人民医院肾内科
出处 《实用医学杂志》 CAS 2008年第3期352-354,共3页 The Journal of Practical Medicine
关键词 糖尿病肾病 抗原 CD29 氧化应激 阿托伐他汀
分类号 R587.2 [医药卫生—内分泌]
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参考文献13

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二级参考文献31

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实用医学杂志
2008年 第3期

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