摘要
目的：探讨补肾生血干膏治疗肾性贫血的作用机理。方法：对２６例慢性肾功能衰竭（ＣＲＦ）贫血患者用补肾生血干膏治疗，观察治疗前后贫血和肾功能的变化，并用红系集落（ＣＦＵ－Ｅ）体外培养法测定血清红细胞生成素（ＥＰＯ）和血清对ＣＦＵ－Ｅ生成的抑制。结果：服药１～２疗程后患者肾功能和贫血程度均有不同程度的改善，血清ＥＰＯ浓度略有增加，而对血清ＣＦＵ－Ｅ生成抑制明显减轻。结论：该药可改善贫血程度，其机理可能是通过清除患者体内ＣＦＵ－Ｅ生成的抑制物来实现的。
To evaluate the therapeutical mechanism of Bushen Shengxue Paste (BSSXP) on anemia. Methods: Chronic renal failure induced anemia patients were treated with BSSXP, clinical manifestation,anemia and renal function as indicators were observed in patients. The erythropoietin (EPO ) and inhibition of colony-forming unit-erythrocyte (CFU-E ) in patients' serum were determined by CFU-E in vitro. Results: The patients' symptoms, renal function and anemia were improved after administration with BSSXP 1～2 course. EPO in serum was slightly increased. The inhibition of CFU-E in patient's serum was significantly decreased. Conclusions: BSSXP could improve the anemia degree, its mechanism might be through clearing the inhibitor of CFU-E in serum.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1997年第6期334-335,共2页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
补肾生血干膏
肾性
贫血
中医药疗法
Bushen Shengxue Paste, renal anemia, erythropoietin, erythropoietic inhibiting factor
