摘要
目的：观察急性心肌梗塞（ａｃｕｔｅｍｙｏｃａｒｄｉａｌｉｎｆａｒｃｔｉｏｎ，ＡＭＩ）患者血浆内皮素（ｅｎｄｏｔｈｅｌｉｎ，ＥＴ）与肾素活性（ｒｅｎｉｎａｃｔｉｖｉｔｙ，ＲＡ）、血管紧张素Ⅱ（ａｎｇｉｏｔｅｎｓｉｎⅡ，ＡＴ－Ⅱ）的变化及葛根素对其影响。方法：将４３例ＡＭＩ患者分为两组，分别接受葛根素（２３例）及极化液（２０例）治疗，以放免法检测治疗前及治疗后不同时期血浆ＥＴ、ＲＡ及ＡＴ－Ⅱ活性的变化。结果：ＡＭＩ患者血浆ＥＴ、ＲＡ及ＡＴ－Ⅱ血活性明显高于健康对照组（Ｐ＜０．０１），且ＥＴ与ＲＡ及ＡＴ－Ⅱ间均存在着显著正相关（Ｐ＜０．０１）；经葛根素治疗后血浆ＥＴ及ＲＡ、ＡＴ－Ⅱ在３天内恢复至正常，而经极化液治疗组血浆ＲＡ及ＡＴ－Ⅱ于７天方恢复接近正常，ＥＴ在１４天才降至正常。结论：葛根素是对ＡＭＩ患者异常反应的神经内分泌系统有重要调节作用的药物。
To study the changes of endothelin (ET), renin activity (RA) and angiotensin Ⅱ (AT-Ⅱ)before and after puerarin treatment in patients with acute myocardial infarction (AMI).Methods: Forty-three patients with AMI were divided into two groups,and were given puerarin and glucose-insulin-kalium(GIK) treatment respectively. Plasma ET, RA and AT-Ⅱ were measured by radioimmunoassay (RIA) before and after treatment in different phases. Results: It showed that plasma ET and RA, AT-Ⅱ levels in AMI were higher than those in control group (P<0.01 ). ET level was conversely correlated with RA and AT-Ⅱ (P< 0.01). After treatment with puerarin,plasma levels of ET,RA and AT-Ⅱ were recovered to normal in 3 days,but these data recovered to nearly normal until 7～14 days in group with GIK treatment. Conclusion: Puerarin might play an important role in regulating the imbalance of ET,RA and AT-Ⅱ of patients with AMI.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1997年第6期339-341,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
葛根素
急性
心肌梗塞
内皮素
中医药疗法
Puerarin
acute myocardial infarction
endothelin
renin-angiotensin system
