冠心病中医辨证与血清E-选择素、细胞间粘附分子-1的关系研究被引量：8

下载PDF

导出

摘要目的:探讨冠心病患者血清可溶性E选择素(sE-Selectin)、可溶性细胞间粘附分子-1(sICAM-1)水平变化的意义及与中医症候的关系。方法:对100例冠心病患者中医辨证分为心血瘀阻证组、痰浊内阻证组、非血瘀痰浊证组;22名健康人作为对照组,用双抗体夹心ELISA法检测血清sE-Selectin、sICAM-1水平,并作出相关性分析。结果:冠心病组sE-Selectin、sICAM-1水平明显高于健康对照组(P<0.05)。冠心病中医各证组sE-Selectin水平痰浊内阻证组>心血瘀阻证组>非血瘀、痰浊证组:sICAM-1水平心血瘀阻证组>痰浊内阻证组>非血瘀、痰浊证组。sE-Selectin与sICAM-1呈正相关。结论:sE-Selectin、sICAM-1水平检测可作为冠心病病情发展的监测指标;sE-Selectin、sICAM-1水平与冠心病中医症候有关联,可作为冠心病中医症候微观辨证的参考指标。

作者杨徐杭汶医宁党琳魏敏慧马晓军田正良辛爱洁

机构地区陕西中医学院陕西中医学院附属医院

出处《四川中医》北大核心 2008年第1期61-62,共2页 Journal of Sichuan of Traditional Chinese Medicine

基金陕西省科技厅课题(2007C234) 陕西省咸阳市课题(XK06015-3)

关键词冠心病中医辨证 E-选择素细胞间粘附分子-1

分类号 R541.4 [医药卫生—心血管疾病]

引文网络
相关文献

参考文献5

1李晓惠,乔守炎,廖敏蕾,徐永慧,高明喜,徐中,顾俊英.急性冠脉综合征患者检测血清E-选择素的意义[J].国际心血管病杂志,2006,33(3):208-210. 被引量：2
2虞华鹏,高成志,刘建民,赵震,赵成军.急性冠脉综合征患者血浆CD_(40)L水平及与血管黏附分子之间关系[J].医学综述,2006,12(11):703-704. 被引量：7
3Nasuno A, Matsubara T, Horl T, et al. Levels of soluble E-selectin and ICAM-1 in the coronarv circulation of patients with stable coronary artery disease: association with the severity of coronary atherosclerosis [J]. Jpn Heart J, 21302, 43:93 - 101
4李艳,韦叶生,张平安,李晓艳,黄从新.冠心病患者E-选择素血清水平及其G98T、S128R基因多态性研究[J].中华心血管病杂志,2004,32(3):229-232. 被引量：17
5袁肇凯,黄献平,谭光波,毛以林,卢芳国,胡志希,田松,李杰,孙贵香.冠心病血瘀证血管内皮细胞功能的检测分析[J].中国中西医结合杂志,2006,26(5):407-410. 被引量：51

二级参考文献23

1胡小勤,陈利国.血管内皮细胞粘附分子与血瘀证相关性探讨[J].陕西中医,2005,26(3):249-250. 被引量：10
2[1]Ross R.Atherescleresis--an inflammatory disease[J].N Engl J Med,1999,340(2):115-126.
3[2]Wenzel K,Felix S,Kleber FX,et al.E-selectin polymorphism and atherosclerosis:an association study[J].Hum Mol Genet,1994,3(11):1935-1937.
4[3]Ye SQ,Usher D,Virgil D,et al.A PstI polymorphism detects the mutation of serinel 28 to arginine in CD 62E gene a risk fector for coronary artery disease[J].J Biomed Sci,1999,6(1):18-21.
5Vanhotte PM.Endothelial dysfunction and atherosclerosis.Eur Heart 1997; 18 (Suppl E):E19-E29.
6Hillis GS,Flapan AD.Cell adhesion molecules in cardiovascular disease:a clinical perspective.Heart 1998 ; 79 (5):429-431.
7Forman MB,Virmani R,Putti DW.Mechanisms and therapy of myocardial reperfusion injury.Circulation1990;81 (Suppl):Ⅳ 69-71.
8Mazzone A,De-Servi S,Ricevuti G,et al.Increased expression of neutrophil and monocyte adhesion molecules in unstable coronary artery disease.Circulation 1993 ;88(2):358-360.
9Mach F, Schonbeck U, Sukhova GK, et al. Functional CD40 ligand is expressed on human vascular endothelial calls, smooth muscle cells, and macrophages : implication for CD40-CD40 ligand signaling in atherosclerosis[J] .Proc Nathl Acad Sci USA, 1997,94(7) : 1931-1936.
10Kotowicz K,Dixon GL, Klein NJ, et al. Biological function of CD40 on human endotheliol cells: cestimulation with CD40 ligand and interleukin-4 selectively induzes exprezesion of vasculay cell adhesion molecule-1 and P-selectin resulting in preferential adhesion of lymphocyte[J]. Immunology,2000,100(4) :441-448.