摘要
为研究头孢美唑和其他４种抗生素的体外抗菌活性，采用美国全国临床检验标准委员会（ＮＣＣＬＳ）推荐的琼脂稀释法测定头孢美唑对４６３株菌的最小抑菌浓度（ＭＩＣ），并与头孢唑啉、头孢呋辛、头孢噻肟、头孢他啶作比较。结果表明，头孢美唑对吲哚阳性的普通变形杆菌和摩根摩根菌活性最高，ＭＩＣ９０为８ｍｇ／Ｌ，其对大肠杆菌、肺炎克氏菌和吲哚阴性的奇异变形杆菌抗菌活性同头孢噻肟，敏感率为８２％～１００％，但略低于头孢他啶（敏感率为８８％～１００％）。头孢美唑对苯唑西林敏感的葡萄球菌也有高活性，其ＭＩＣ９０为４ｍｇ／Ｌ。研究提示，头孢美唑对所研究的大多数肠杆菌科细菌及苯唑西林敏感的葡萄球菌有较高活性。
We compared the in vitro antibacterial activity of cefmetazole and other 4 antibiotics against clinical isolates. The minimal inhibitory concentration (MIC) of cefmetazole against 463 isolates was determined by standard (NCCLS) agar dilution testing, and compared with that of cefazolin, cefuroxime, cefotaxime and ceftazidime. The results showed that cefmetazole was the most effective in 5 antibiotics to indole (+) P. vulgaris and M. morganii (MIC 90 8 mg/L), and cefmetazole had the same activity as cefotaxime (sensitive 82%～100%), but less activity than ceftazidime (sensitive 88%～100%) against E. coli, K. pneumoniae and P. morabilis . To oxacillin sensitive staphylococci, cefmetazole was highly active, with the MIC 90 of 4 mg/L. Our results indicate that cefmetazole is highly active against Enterobacteriaceae and oxacillin sensitive staphylococci.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1997年第8期540-542,共3页
Chinese Journal of Internal Medicine
关键词
头孢美唑
抗生素
抗菌活性
Cephalosporins Antibacterial activity
