摘要
应用组织学、组织化学和电镜方法研究了３０例癫痫病人病灶区手术切除标本脑组织的形态学和神经递质变化。发现引起癫痫发作的多种病灶（如胶质瘤、胶质疤痕、肉芽组织、血管畸形、寄生虫病等）除该疾病所特有的病理形态学改变外，还具有共同的神经形态学和神经递质改变：神经细胞核固缩、染色质边集、核周质水肿、尼氏质减少或消失、胞体皱缩、数量减少。同时，星形胶质细胞和小胶质细胞大量增生。尤其值得注意的是，在大多数病灶区增生的胶质细胞呈谷氨酸免疫反应。我们认为：这提示在慢性癫痫情况下，胶质细胞合成、贮存的摄取谷氨酸的能力增强。因而，即使在病灶区神经细胞受损、数量减少的情况下，仍能保持一个相当大的谷氨酸库，并可在一定的因素诱导下，释放至周围脑组织，导致癫痫的再发作。本研究为慢性癫痫的反复发作提供了可能的神经化学依据。
The morphological and neurotransmitter changes of excised human epileptic focuses have been studied by histological,immunohistochemical and ultrastructural methods.Is was found that besides the disease specially possessed pathological changes(for example,glioma,glial scar,granulation tissue,deformity of blood vessel,parasitic disease of brain,etc.)there were common morphological and neurotransmitter changes in all cases,including neuronal karyopyknosis,marginal collection of chromatin,edema of perikaryon,loss of Nissl`s bodies,shrink of cell body and loss of neruons.Meanwhile,astrocytes and microglial cells massively proliferated.It was worthy to be noticed that proliferated neuroglial cells demonstrated positive glutamate(Glu)immunoreaction in most cases.Above mentioned results suggested that under chronic epileptic condition the ability of synthesizing,storing and absorbing Glu enhanced,so that keeping an abundent Glu pool even in the cases in which the neruons were seriously damaged and their number remarkable reduced.On the other hand,under influences of some factors,stored Glu could be released into surrounding brain tissue and leading to a relapse of epilepsy.Present study provided a new neurochemical basis for the repeated seizures of epilepsy.
出处
《解剖学报》
CAS
CSCD
北大核心
1997年第3期225-229,共5页
Acta Anatomica Sinica
基金
国家自然科学基金
