摘要
目的：探讨颈内动脉插管溶栓（ＰＩＥＡＴ）治疗急性脑梗塞的应用价值。方法：用颈内动脉插管注射组织型纤溶酶原激活因子（ｔＰＡ）溶栓治疗急性脑梗塞５０例（Ａ组），与同期颈内动脉插管注射尿激酶（ＵＫ）溶栓１８０例（Ｂ组）和外周静脉静滴ＵＫ１９０例（Ｃ组）进行对比，观察患者失语、昏迷、出血、死亡情况及肌力恢复情况。结果：肌力恢复：Ａ组＞Ｂ组＞Ｃ组，Ｐ＜０．０５或＜０．０１；失语、昏迷症状改善：Ａ组＞Ｂ组＞Ｃ组（Ｐ均＜０．０１）；病死率、出血并发症的发生率：Ａ组＜Ｂ组＜Ｃ组，Ｐ均＜０．０１。结论：ＰＩＥＡＴ治疗急性脑梗塞疗效优于周围静脉给药，ｔＰＡ的颈内动脉溶栓效果优于ＵＫ。
Objective:To investigate the applicative value of percutaneous intubation endotrachelous artery thrombolysis(PIEAT) for treating acute cerebral infarct.Methods:50 cases of acute cerebral infarction were treated with injecting tissue plasminogen activator(tPA) PIEAT(group A) and compared with 180 cases injected urokinase (UK) PIEAT(group B) and 190 cases with UK per intravenous drip(group C).In addition,to observe the signs and symptoms change,include aphasia,consciousness,bleeding,mortality and myodynamic restoration.Results:Myodynamic restoration:group A>B>C, P <0 05 or <0 01;mortality and complicating bleeding:group A<B<C,all P <0 01.Conclusions:The therapeutic efficacy of PIEAT on acute cerebral infarct was superior to that with perintravenous drip and the thrombolytic efficacy of tPA iss superior to UK.
出处
《中国危重病急救医学》
CAS
CSCD
1997年第6期332-334,共3页
Chinese Critical Care Medicine
关键词
颈内动脉插管
脑梗塞
T-PA
治疗
percutaneous intubation endotrachelous artery thrombolysis
acute cerebral infarct
tissue plasminager activator
