摘要
目的观察卷柏水部位对受了射线照射小鼠造血系统的辐射防护作用。方法①KM种小鼠于接受8．0Gy ^60Coγ射线照射前1周给药，观察受照射小鼠的30d存活率、死亡动物平均存活时间、受照射小鼠体重变化和外周血白细胞数变化；②KM种小鼠于6．0Gy ^60Coγ射线照射前72、48和24h，以及照射后即刻灌服药物或蒸馏水，观察受照射小鼠骨髓细胞周期及凋亡率的变化。结果卷柏水部位可明显提高照射后小鼠30d的存活率、死亡动物平均存活时间和小鼠外周血白细胞数，抑制射线引起的小鼠体重的下降；另外，它还可降低受照射小鼠骨髓细胞G0/G1期细胞百分率，升高其G2/M、S期细胞百分率，并可明显降低其细胞凋亡率。结论卷柏水部位对照射损伤小鼠的造血系统有一定的辐射防护作用。
Objective To investigate the protective effects of the water part of Selaginella Tamariscina on hematopoietic system in γ-rays irradiated mice. Methods ① Kunming mice were administered with drugs or water 1 week before exposure to 8.0 Gy ^60 Co γ-rays, 30 d survival, the average life-span of dead mice, the changes in the mice＇ weights and the number of WBC after irradiation were recorded. ② Kunming mice were administered with drugs or water at hours 72, 48, 24 before and immediately after exposure to 6.0 Gy ^60 Co γ- rays, the changes of apoptosis and cell cycle of bone marrow cell in irradiated mice were recorded. Results The water part of SelagineUa Tamariscina could increase significantly the 30 d survival, the average life-span of dead mice and the number of WBC, inhibit the loss of the weight in irradiated mice; decrease the percentages of bone marrow cell in G0/G1 phase, increase the percentages of bone marrow cell in G2/M and S phase, and decrease significantly apoptosis of bone marrow cell in irradiated mice, Conclusions The water part of Selaginella Tamariscina has protective effects on hematopoietic system in irradiated mice.
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
2008年第1期35-38,共4页
Chinese Journal of Radiological Medicine and Protection
基金
教育部博士点基金资助项目（20050026012,2006000256019）
河南省高校新世纪优秀人才支持计划（2006HANCET-08）
关键词
卷柏水部位
细胞周期
细胞凋亡
骨髓细胞
Water part of Selaginella Tamariscina
Cell cycle
Apoptosis
Bone marrow cell
