摘要
目的:探讨外周血D-二聚体(D-D),纤维蛋白原(FG)浓度的变化与慢性心功能不全患者NYHA心功能分级及超声心动图所测指标的关系和临床意义.方法:采用酶联免疫吸附法测定正常对照组(n=20),心脏病心功能正常组(n=31),慢性心功能不全组(n=61)D-D和FG的浓度及超声心动图指标,评价NYHA心功能分级并进行相关性分析.结果:与正常对照组比较,心脏病心功能正常组和慢性心功能不全组D-D和FG浓度升高,左心房内径(LAD)和左心室舒张末内径(LVEDD)均增大,左心室射血分数(LVEF)和左室短轴缩短率(FS)均减小(P均<0.05),且D-D和FG与纽约心功能分级相关(P均<0.05).结论:慢性心功能不全患者血液存在着凝血和纤溶激活,血浆D-D和FG水平与心力衰竭严重程度密切相关,且存在心室结构的重塑.
AIM： To explore the clinical significance of levels of plasma D-dimer （ D-D ） and fibrinogen （ FG ） and correlation among their concentrations, NYHA classification and the parameters measured by echocardiography. METHODS： We measured the concentrations of D-D and FG with enzyme-linked immunoassay and compared among normal control group （ n = 20 ）, heart disease but non-dysfunction group（ n = 31 ）and chronic heart failure group（ n = 61 ）. RESULTS： Compared with control group, the plasma levels of D-D and FG in heart disease but non-dysfunction group and chronic heart failure group elevated and were negatively correlated with left ventricle ejection fraction （LVEF） and fraction shortening（ FS）, and positively correlated with left atrial diameter （LAD） and left ventricle end-diastolic diameter （LVEDD）. The correlation between the concentration of D-D, FG and NYHA classification was significant （ P 〈 0. 05 ）. CONCLUSION： D-D and FG have a close correlation with the cardiac function and echocardiogram parameters in chronic heart failure which shows the evident hypercoagulability and activated congulation/fibrinolysis system. Meanwhile, there is a correlation of D-D and FG concentrations with their NYHA class and echocardiographic parameters and ventricular structure remodeling.
出处
《第四军医大学学报》
北大核心
2008年第4期354-356,共3页
Journal of the Fourth Military Medical University
