摘要
目的探讨survivin在乳腺癌中的表达及其临床意义。方法应用免疫组织化学方法检测66例乳腺癌及22例乳腺腺瘤中survivin的表达。结果①survivin在乳腺腺瘤组织中表达的阳性率明显高于乳腺癌组织(P<0.05);②survivin与患者的年龄和乳腺癌的位置无关(P>0.05),而与淋巴结是否转移有关(P<0.05)。结论①survivin蛋白可以通过抑制细胞凋亡对乳腺癌的发生、发展起重要作用;②检测乳腺癌中survivin的表达对制定化疗方案具有重要意义。
Objective To study the expression of survivin in breast carcinomas and its significance. Methods The expression of survivin was studied in 66 breast carcinoma samples and 22 breast adenoma samples by immunohistochemical technique. Rerults The expression of survivin in breast adenoma was significantly higher than that in breast carcinomas （ P 〈 0. 05 ）. The expression of survivin was not correlated with the patient＇s age and breast carcinomas position; however, it correlated with lymph node metastases （ P 〈 0. 05 ）. Conclusion Survivin may play an important role in the pathway of carcinogenesis and progression by inhibiting appotosis. The detection of the expression of survivin in breast carcinomas is a useful tool to guide clinical decision-making.
出处
《癌症进展》
2008年第1期87-90,共4页
Oncology Progress
