摘要
学术背景:目前,大口径人造血管的研究已取得突破性进展,在临床上得到广泛应用。而在小口径人造血管(直径小于6mm)研究方面,由于存在血管栓塞以及组织相容性等方面的核心问题没有得到有效解决,离实际应用还有很大的距离。目的:比较了几种已有的人造血管材料在生物相容性和顺应性上的区别,探寻最佳的小口径人造血管材料。检索策略:由本文作者应用计算机检索中国知网(www.cnki.net)及Medline(www.pubmed.com)1985-01/2007-08与人造血管的生物相容性、小口径人造血管的顺应性有关的文献,中文检索词"人造血管,聚氨酯,组织相容性";英文检索词"Vasculargrafts,Polyurethane,Biocompatibility"。初检得到138篇文献,包括中文32篇,英文106篇。文献评价:排除因研究目的与本研究无关者42篇,内容重复性的研究67篇,保留29篇中英文文献进一步分析。其中动物实验和在体、离体、细胞学实验20篇,综述、述评、讲座类文献9篇。资料综合:理想的小口径人造血管是有良好的物理稳定性、力学性能、生物相容性、抗凝血性及抗感染性,其中力学性能和组织血液相容性是保证血管长期稳定性及通畅性的主要因素,也是突破人造血管技术的关键。在生物相容性方面,较好的选择为聚氨酯材料。而在材料的生物稳定性能上,较佳的是不易降解的聚氨酯、膨化聚四氟乙烯材料。结论:以上几种材料相较而言,聚氨酯在生物相容性及力学性能上均较好,但在长期使用过程中仍可发现聚氨酯在体内会出现老化降解和钙化现象。因此,聚氨酯材料展开多方面的研究工作是有重大意义的。
BACKGROUND： At present, a breakthrough study has been achieved for the big-caliber vascular grafts, which are widely applied in the clinical practice. While there are still some unsolved key problems of small-caliber vascular grafts, such as vascular embolism and histocompatibility, which obstructs the practical use of small-caliber vascular grafts. OBJECTIVE： To compare the biocompatibility and compliance of several vascular grafts, and probe the best material for small-diameter vascular grafts. RETRIEVAL STRATEGY： A computer-based search was undertaken in www.cnki.net and Mediine （www.pubmed.com） to identify the articles about the biocompatibility of vascular graft, as well as compliance of small-diameter vascular grafts between January 1985 and August 2007, with the key words of ＂Vascular grafts, Polyurethane, Biocompatibility＂ in Chinese and English. After the primary check, a total of 138 articles were collected, including 32 Chinese ones and 106 English ones. LITERATURE EVALUATION： There were 42 articles excluded due to unrelated objectives and 67 articles due to repeated contents, finally 29 literatures were involved in the analysis, including 20 ones regarding animal experiments, and in vivo, ex vivo, cytological trials, 9 ones regarding reviews, commentaries and lectures. DATA SYNTHESIS： The ideal small-diameter vascular grafts require good physical stability, mechanical property, biocompatibility, anticoagulant property and infectivity resistance. Among them, mechanical property and biocompatibility have a crucial role in ensuring the long-term stability and patency of vessels, as well as advance vascular graft technique. Polyurethane is preferred owing to its biocompatibility; while the undegradable polyurethane and expanded polytetrafiuoroethylene are favorable regarding biological stability. CONCLUSION： Polyurethane is satisfactory in aspects of biocompatibility and mechanical property, but degradation and calcification may occur after a long-term use. Therefore it is crucial to develop versatile investigations of polyurethane materials.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第1期125-128,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
