摘要
目的观察壮药白莲Ⅰ号方对小鼠移植性肉瘤S180的抑瘤作用和其对小鼠血浆白细胞介素-18(IL-18)的影响,以探讨该药抑制肿瘤的作用是否与诱生小鼠血浆中IL-18的含量有关。方法建立小鼠移植肉瘤S180模型。用大、中、小剂量壮药白莲Ⅰ号方及环磷酰胺治疗肉瘤S180小鼠,观察其抑瘤率及血浆IL-18的含量。结果白莲Ⅰ号方在一定剂量范围内对荷瘤小鼠的抑瘤率>30%,并且白莲Ⅰ号方各剂量组均有促进荷瘤小鼠IL-18生成的作用趋势,改善荷瘤小鼠的生存质量。结论白莲Ⅰ号方能有效抑制小鼠S180实体瘤的生长,存在量-效关系;白莲Ⅰ号方具有诱生荷瘤S180小鼠血浆IL-18的作用,具有良好的免疫调节作用。
Objective To study the effect of Bai Lian Prescription No. 1 on tumor and IL - 18 level in sarcoma S180 mice. Methods Sarcoma 180 tumor mice were treated with high,medium and low doses of Bai Lian Presription No. 1 and cyclophosphamide （CTX） . The inhibiting rate and the content of IL-18 were assayed in mice. Results The tumor inhibiting rate on tumor mice was over 30% , and it could promote the prduction of on IL - 18 in sarcoma S180 mice, improve living quality of the tumor mice. Conclusion Bai Lian Prescription No. 1 can inhibit the growth of transplanted S180 tumor of mice significantly in a dose - dependent manner promote the production of IL -18 in sarcoma S180 mice, which has a good immunoloregulation effect.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2008年第2期449-450,共2页
Lishizhen Medicine and Materia Medica Research
